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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Atlas Venture Life Science Advisors LLC	[2023-03-31]	SOLE	5,836,874.0	5,836,874.0
Northpond Ventures LLC	[2023-03-31]	SOLE	4,214,498.0	4,214,498.0
Artal Group S.A.	[2023-03-31]	DFND	2,243,352.0	2,243,352.0
Citadel Advisors LLC	[2023-03-31]	DFND	2,161,796.0	2,161,796.0
Deerfield Management Company LP Series C	[2023-03-31]	DFND	2,052,010.0	2,052,010.0
Deep Track Capital LP	[2023-03-31]	SOLE	2,025,137.0	2,025,137.0
BVF Inc/IL	[2023-03-31]	DFND	0.0	1,813,633.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	723,042.0
Cormorant Asset Management LP	[2023-03-31]	DFND	616,786.0	616,786.0
Pivotal Bioventure Partners Investment Advisor LLC	[2023-03-31]	DFND	0.0	560,595.0
Rock Springs Capital Management LP	[2023-03-31]	SOLE	471,958.0	471,958.0
OrbiMed Advisors LLC	[2023-03-31]	SOLE	448,891.0	448,891.0
Harvard Management Co Inc	[2023-03-31]	SOLE	289,460.0	289,460.0
Trustees of Columbia University in the City of New York	[2023-03-31]	SOLE	192,973.0	192,973.0
Logos Global Management LP	[2023-03-31]	SOLE	188,390.0	188,390.0
DAFNA Capital Management LLC	[2023-03-31]	SOLE	172,308.0	172,308.0
Laurion Capital Management LP	[2023-03-31]	SOLE	130,200.0	130,200.0
Geode Capital Management LLC	[2023-03-31]	DFND	112,392.0	112,392.0
Barclays PLC	[2023-03-31]	SOLE	104,248.0	104,248.0
BlackRock Inc.	[2023-03-31]	SOLE	102,086.0	102,086.0
Citigroup Inc	[2023-03-31]	DFND	91,398.0	91,398.0
FMR LLC	[2023-03-31]	DFND	86,650.0	86,724.0
Millennium Management LLC	[2023-03-31]	SOLE	71,381.0	71,381.0
Susquehanna International Group LLP	[2023-03-31]	DFND	58,718.0	58,718.0
Morgan Stanley	[2023-03-31]	DFND	20,524.0	58,344.0
State Street Corp	[2023-03-31]	DFND	35,739.0	35,739.0
Jane Street Group LLC	[2023-03-31]	DFND	27,184.0	27,184.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	24,826.0	24,826.0
Northern Trust Corp	[2023-03-31]	DFND	0.0	22,235.0
Bank of America Corp /DE/	[2023-03-31]	DFND	0.0	19,322.0
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