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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
SB Investment Advisers UK Ltd	[2025-06-30]	SOLE	16,684,041	16,684,041
BlackRock, Inc.	[2025-06-30]	SOLE	15,798,722	16,153,190
Vanguard Group Inc	[2025-06-30]	SOLE	0	13,068,121
Arch Venture Management LLC	[2025-06-30]	SOLE	0	12,916,663
State Street Corp	[2025-06-30]	DFND	5,017,983	5,254,712
FMR LLC	[2025-06-30]	DFND	3,551,294	3,558,655
Citadel Advisors LLC	[2025-06-30]	DFND	3,514,217	3,514,217
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	2,702,988	2,862,157
OrbiMed Advisors LLC	[2025-06-30]	DFND	671,181	2,380,715
Geode Capital Management LLC	[2025-06-30]	DFND	2,252,420	2,252,420
Morgan Stanley	[2025-06-30]	DFND	1,485,139	1,633,690
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	1,292,921	1,293,016
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,290,008	1,290,138
Ikarian Capital LLC	[2025-06-30]	SOLE	1,068,062	1,068,062
Renaissance Technologies LLC	[2025-06-30]	SOLE	1,064,500	1,064,500
Aberdeen Group plc	[2025-06-30]	DFND	1,006,891	1,006,891
Northern Trust Corp	[2025-06-30]	DFND	878,091	879,914
Schroder Investment Management Group	[2025-06-30]	SOLE	840,433	840,433
Artisan Partners Limited Partnership	[2025-06-30]	SOLE	724,847	791,611
Voloridge Investment Management LLC	[2025-06-30]	SOLE	789,506	789,506
Nordea Investment Management AB	[2025-06-30]	DFND	0	704,377
Hudson Bay Capital Management LP	[2025-06-30]	SOLE	696,000	696,000
Royal Bank of Canada	[2025-06-30]	DFND	689,162	689,162
Clarius Group, LLC	[2025-06-30]	SOLE	617,535	617,535
Bank of New York Mellon Corp	[2025-06-30]	DFND	564,165	612,470
Prudential Financial Inc	[2025-06-30]	DFND	602,527	610,452
Millennium Management LLC	[2025-06-30]	SOLE	609,292	609,292
Ensign Peak Advisors, Inc	[2025-06-30]	SOLE	582,981	582,981
Baker Bros Advisors LP	[2025-06-30]	SOLE	542,539	542,539
Corient Private Wealth LLC	[2025-06-30]	SOLE	509,052	518,684
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