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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Point72 Asset Management LP	[2025-06-30]	DFND	0	5,895,069
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	4,536,182	4,536,182
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,144,092
Tang Capital Management LLC	[2025-06-30]	OTR	0	3,100,000
Marshall Wace LLP	[2025-06-30]	OTR	0	2,396,823
Vestal Point Capital LP	[2025-06-30]	SOLE	2,000,000	2,000,000
Citadel Advisors LLC	[2025-06-30]	DFND	1,827,581	1,827,581
Millennium Management LLC	[2025-06-30]	SOLE	1,405,754	1,405,754
BlackRock, Inc.	[2025-06-30]	SOLE	1,360,412	1,368,005
SIO Capital Management LLC	[2025-06-30]	SOLE	1,307,964	1,307,964
Redmile Group LLC	[2025-06-30]	SOLE	1,114,529	1,114,529
Ikarian Capital LLC	[2025-06-30]	SOLE	967,590	967,590
Connor Clark & Lunn Investment Management Ltd	[2025-06-30]	SOLE	945,206	945,206
Sectoral Asset Management Inc	[2025-06-30]	SOLE	0	931,620
Bank of America Corp /DE/	[2025-06-30]	DFND	0	838,387
Monaco Asset Management SAM	[2025-06-30]	SOLE	761,891	761,891
Geode Capital Management LLC	[2025-06-30]	DFND	711,844	711,844
AQR Capital Management LLC	[2025-06-30]	DFND	705,277	705,280
Acadian Asset Management LLC	[2025-06-30]	DFND	616,934	616,934
Goldman Sachs Group Inc	[2025-06-30]	DFND	580,364	580,364
Sphera Funds Management Ltd	[2025-06-30]	DFND	555,814	555,814
Susquehanna International Group LLP	[2025-06-30]	OTR	486,980	546,680
Morgan Stanley	[2025-06-30]	DFND	517,589	521,018
JPMorgan Chase & Co	[2025-06-30]	DFND	457,919	457,919
Macquarie Group Ltd	[2025-06-30]	SOLE	430,000	430,000
Walleye Capital LLC	[2025-06-30]	SOLE	422,094	422,094
Qiming US Ventures Management LLC	[2025-06-30]	SOLE	412,225	412,225
Jane Street Group LLC	[2025-06-30]	DFND	400,597	400,597
UBS Group AG	[2025-06-30]	DFND	367,509	367,509
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	346,911	346,911
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