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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2023-03-31]	DFND	7,604,120.0	7,604,341.0
Citadel Advisors LLC	[2023-03-31]	DFND	3,033,723.0	3,033,723.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	474,514.0	2,670,141.0
Capital International Investors	[2023-03-31]	DFND	2,377,784.0	2,377,784.0
venBio Partners LLC	[2023-03-31]	SOLE	2,298,833.0	2,298,833.0
BlackRock Inc.	[2023-03-31]	SOLE	2,026,212.0	2,048,601.0
Avidity Partners Management LP	[2023-03-31]	SOLE	1,917,800.0	1,917,800.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,745,283.0
Janus Henderson Group PLC	[2023-03-31]	DFND	0.0	1,598,416.0
RTW Investments LP	[2023-03-31]	SOLE	1,388,881.0	1,388,881.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	1,350,530.0	1,350,540.0
Lord Abbett & Co LLC	[2023-03-31]	SOLE	1,129,749.0	1,262,000.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	1,069,400.0
Holocene Advisors LP	[2023-03-31]	SOLE	1,036,513.0	1,036,513.0
Driehaus Capital Management LLC	[2023-03-31]	SOLE	776,713.0	936,121.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	870,505.0
Boxer Capital, LLC	[2023-03-31]	OTR	850,000.0	850,000.0
Redmile Group LLC	[2023-03-31]	SOLE	815,774.0	815,774.0
TCG Crossover Management LLC	[2023-03-31]	SOLE	815,724.0	815,724.0
Qiming US Ventures Management LLC	[2023-03-31]	SOLE	746,370.0	746,370.0
Pictet Asset Management Sa	[2023-03-31]	DFND	1.0	744,725.0
Deerfield Management Company LP Series C	[2023-03-31]	DFND	617,000.0	617,000.0
Vivo Capital LLC	[2023-03-31]	SOLE	602,075.0	602,075.0
State Street Corp	[2023-03-31]	DFND	563,232.0	599,827.0
Morgan Stanley	[2023-03-31]	DFND	549,821.0	595,876.0
OrbiMed Advisors LLC	[2023-03-31]	DFND	195,000.0	585,000.0
T. Rowe Price Investment Management, Inc.	[2023-03-31]	SOLE	172,725.0	564,636.0
Geode Capital Management LLC	[2023-03-31]	DFND	537,142.0	537,142.0
Artal Group S.A.	[2023-03-31]	DFND	535,812.0	535,812.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	504,915.0	504,915.0
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