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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Matrix Capital Management Company LP	[2025-06-30]	SOLE	13,959,973	13,959,973
Millennium Management LLC	[2025-06-30]	SOLE	3,476,808	3,476,808
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,862,907
Opaleye Management Inc	[2025-06-30]	SOLE	1,924,300	1,924,300
BlackRock, Inc.	[2025-06-30]	SOLE	1,728,233	1,741,747
Almitas Capital LLC	[2025-06-30]	SOLE	1,599,266	1,599,266
Tang Capital Management LLC	[2025-06-30]	OTR	0	1,550,000
Renaissance Technologies LLC	[2025-06-30]	SOLE	1,529,553	1,529,553
Tybourne Capital Management HK Ltd	[2025-06-30]	SOLE	1,478,152	1,478,152
Decheng Capital LLC	[2025-06-30]	SOLE	1,323,327	1,323,327
Two Sigma Advisers LP	[2025-06-30]	SOLE	1,225,726	1,275,914
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	1,197,624	1,197,624
GSA Capital Partners LLP	[2025-06-30]	SOLE	1,133,375	1,133,375
Morgan Stanley	[2025-06-30]	DFND	1,031,542	1,097,651
Two Sigma Investments LP	[2025-06-30]	SOLE	1,093,053	1,093,053
PRIMECAP Management Co/CA/	[2025-06-30]	SOLE	1,008,520	1,027,620
Balyasny Asset Management LP	[2025-06-30]	SOLE	970,862	970,862
Pfizer Inc	[2025-06-30]	SOLE	953,834	953,834
Goldman Sachs Group Inc	[2025-06-30]	DFND	861,482	861,767
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	777,171	857,582
Bank of America Corp /DE/	[2025-06-30]	DFND	0	713,315
Jane Street Group LLC	[2025-06-30]	DFND	664,061	664,061
Geode Capital Management LLC	[2025-06-30]	DFND	618,167	618,167
Peapod Lane Capital LLC	[2025-06-30]	SOLE	446,010	559,213
JPMorgan Chase & Co	[2025-06-30]	DFND	550,447	550,447
Woodline Partners LP	[2025-06-30]	SOLE	530,582	530,582
5AM Venture Management LLC	[2025-06-30]	SOLE	490,000	490,000
Citadel Advisors LLC	[2025-06-30]	DFND	484,340	484,340
AQR Capital Management LLC	[2025-06-30]	DFND	425,097	425,105
Man Group plc	[2025-06-30]	DFND	100,427	406,344
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