Foresite Capital Management LLC

ITEM 5 – FEES AND COMPENSATION

Management Fees

Foresite Capital is compensated for its advisory services through asset-based management fees. With
respect to the Funds and SPVs, the annual management fee is typically 2% of the aggregate capital
commitments, in the relevant Fund, during the investment period (as defined in the relevant Client
Agreement). However, certain Funds and SPVs have no management fee, and one Fund has varied
management fees for investors ranging from 2.5% to 1.8%.

After the investment period, the management fee is reduced annually or quarterly as detailed in the
relevant governing documents.

The management fee is typically paid quarterly in advance. Foresite Capital, or the relevant Advisory
Affiliate, may, waive or reduce the management fee in its sole discretion.

Carried Interest

In addition, as described in more detail in Item 6 below, Advisory Affiliates receive performance-based
profit distributions (commonly referred to as “Carried Interest”) in each of the Funds and SPVs once all
capital contributions have been returned to the Investors in the Fund (pursuant to the terms in each Client
Agreement). Certain Advisory Clients have higher carried interest than others. Foresite Capital seeks to
mitigate any conflict of interest related to this by adhering to the Client Agreements, and the allocation
policy in the Compliance Manual.

Compensation for Advisory Services

Foresite Capital, or an Advisory Affiliate, is paid the management fees applicable to the appropriate
Advisory Client directly from the Advisory Client’s assets. Performance-based profit distributions
described in Item 6 below are paid to the relevant Advisory Affiliates when earned. Investors do not have
the ability to choose to be billed directly for management fees.

Foresite Capital and its personnel can be expected to receive certain intangible and/or other benefits
and/or perquisites arising or resulting from their activities on behalf of the Advisory Clients that will
neither be subject to an offset against any management fees nor will otherwise be shared with the
Advisory Clients and/or portfolio companies. For example, airline travel or hotel stays incurred as an
Advisory Client expense typically result in cash rebates, “miles,” “points” or credit in loyalty/status
programs, and such benefits and/or amounts will, whether or not de minimis or difficult to value, inure
exclusively to Foresite Capital and/or such personnel even though the cost of the underlying service is
borne by the Advisory Clients and/or portfolio companies.
Expenses

The Advisory Affiliates or Foresite Capital will pay certain ordinary and customary expenses out of the
management fee (including salaries, wages, rent, communication costs, equipment and other overhead
expenses).

The Advisory Clients will bear all other expenses of the Advisory Clients, which generally include
(depending on the Advisory Client) all costs and expenses incurred in respect of (including such costs and
expenses in connection with the termination, cancellation or abandonment of a potential investment that is
not consummated): the purchase, holding or sale or exchange or other disposition of securities, including
expenses incurred in connection with the research, evaluation, due diligence, acquisition, monitoring or

disposition of investments, including sales commissions, third party advisers and consultants (it being
understood that such costs and expenses may include a carried interest or similar performance-based
compensation payable, which shall not reduce the amount of carried interest distributions payable to the
General Partner), consulting fees; appraisal fees; third party sourcing fees (including fees to introducers,
intermediaries and brokers, including performance based and success-based compensation, warrants,
grants or any other form of compensation); taxes; brokerage fees, underwriting commissions and
discounts, and legal, accounting, investment banking, consulting (including work done by an affiliate of
Foresite Capital), information services and professional fees in contemplation of an investment by the
Advisory Client (whether or not consummated) paid to persons other than the Advisory Affiliates; real
property or personal property taxes on investments; preparation of the Advisory Client’s tax returns,
including Schedule K-1 and the costs of creating, printing and distributing such materials; block trades;
short sales; clearing and settlement charges (including reconciliation services); proxy research and voting
and class action-related services; brokerage fees; prime brokerage and futures commission merchants
fees, commission and expenses; obtaining research and market data (including any information
technology hardware, software or other technology incorporated into the cost of obtaining such research
and market data, evaluation and monitoring or investment opportunities, news and quotation equipment,
services and any fees to third-party providers of research and/or portfolio risk management services and
other information in connection with the investigation of investment opportunities); travel expenses
related to the identification, research, evaluation, due diligence, acquisition, monitoring or disposition of
investments (including internal portfolio reviews), such travel expenses include air travel (which may
include the use of private, first-class and business) (private air travel is subject to limits explained in
internal compliance document), hotels and meals, travel expenses in connection with attending industry
conferences and for purposes of conducting due diligence on and monitoring or informing valuations of
investments (current or prospective); the reorganization or recapitalization of an Advisory Client, and
tender offer for interests in the Advisory Client or any other secondary transaction, whether or not
consummated; complying with provisions of any side letter, unreimbursed costs and expenses of a
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ITEM 7 – TYPES OF CLIENTS

Foresite Capital provides investment advisory services to the Advisory Clients described in Item 4 above.
All Investors in the Advisory Clients are “accredited investors” (as defined in Regulation D under the
Securities Act of 1933) and “qualified clients” (as defined in Rule 205-3 of the Investment Advisers Act
of 1940, as amended (the “Advisers Act”)). All Investors in the Funds after Foresite Capital Fund I, L.P.2,
and the SPVs launched in 2021, are also “qualified purchasers” (as defined in section 2(a)(51)(A) of the
Investment Company Act of 1940) or “knowledgeable employees (as defined in Rule 3c5(a)(4) under the
Investment Company Act of 1940).

Any new Advisory Client launched by Foresite Capital will have different terms than those summarized
above. Foresite Capital will generally wait to update this Brochure to reflect the terms of any such new
fund until the annual amendment.