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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Syncona Portfolio Ltd	[2023-03-31]	OTR	0.0	11,086,909.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	2,591,366.0	2,591,366.0
Artal Group S.A.	[2023-03-31]	DFND	2,255,375.0	2,255,375.0
Redmile Group LLC	[2023-03-31]	SOLE	1,608,089.0	1,608,089.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	1,413,809.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	202,433.0	380,233.0
Morgan Stanley	[2023-03-31]	DFND	283,309.0	283,659.0
AXA Sa	[2023-03-31]	DFND	282,028.0	282,028.0
Millennium Management LLC	[2023-03-31]	SOLE	127,249.0	127,249.0
Forefront Analytics LLC	[2023-03-31]	SOLE	75,625.0	75,625.0
Citadel Advisors LLC	[2023-03-31]	DFND	67,246.0	67,246.0
Geode Capital Management LLC	[2023-03-31]	DFND	21,590.0	21,590.0
Bank of America Corp /DE/	[2023-03-31]	DFND	0.0	15,295.0
Susquehanna International Group LLP	[2023-03-31]	DFND	13,900.0	13,900.0
UBS Group AG	[2023-03-31]	SOLE	12,379.0	12,379.0
Endurance Wealth Management Inc	[2023-03-31]	SOLE	2,000.0	2,000.0
JPMorgan Chase & Co	[2023-03-31]	DFND	989.0	989.0
Royal Bank of Canada	[2023-03-31]	DFND	35.0	35.0
Concourse Financial Group Securities Inc	[2023-03-31]	SOLE	0.0	0.0
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