RA Capital Management LP

ITEM 5 – FEES AND COMPENSATION

Within the Healthcare Funds, expenses related to private investments that are Special
Investments are not necessarily allocated pro rata among all Healthcare Fund Investors, due
to differing levels of participation in Special Investments. The Nexus Funds will invest in
substantially the same private investments as the Healthcare Funds during the Nexus Funds’
Investment Period (as defined in the Nexus Fund offering documents) and will also bear
expenses specifically related to such investments, on a pro rata basis.

95161013_3                                                                                    12

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Item 7 – Types of Clients
As previously described in Item 4, RA Capital’s Advisory Clients consist of the Healthcare
Funds, the Nexus Funds, the Structured Capital Funds, the Planetary Health Funds, as well as
the Account. With respect to the Funds, any initial and additional subscription minimums
(as applicable) are disclosed in the relevant offering documents and may be waived or
modified by RA Capital or its affiliates (as the case may be). The Funds are open only to
certain financially sophisticated investors who meet eligibility criteria. Generally, with respect
to separately managed accounts, RA Capital determines the minimum investment amounts
on a case-by-case basis. Typically, such accounts involve significant minimum investments.

Certain institutions may invest in one or more Funds offered by RA Capital through their
endowments or other investment mechanisms. RA Capital maintains an active diligence of
the foundational science activities underway at major institutions. RA Capital may be
incentivized to fund research of, license the assets of, or otherwise invest in an institution
which is an investor in one or more of our Funds. The investment process is team oriented
and science-based, with limited visibility into the limited partners of our Funds, minimizing
the risk created by this conflict.

95161013_3                                                                                         17

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