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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
EcoR1 Capital LLC	[2025-06-30]	SOLE	27,404,070	27,404,070
Long Focus Capital Management LLC	[2025-06-30]	SOLE	23,756,687	23,756,687
Two SEAS Capital LP	[2025-06-30]	SOLE	22,580,701	22,580,701
NEA Management Company LLC	[2025-06-30]	DFND	17,079,778	17,079,778
MPM Asset Management LLC	[2025-06-30]	SOLE	4,809,677	4,809,677
MPM BioImpact LLC	[2025-06-30]	SOLE	4,411,821	4,411,821
Morgan Stanley	[2025-06-30]	DFND	4,217,865	4,232,268
Rock Springs Capital Management LP	[2025-06-30]	SOLE	2,483,468	2,483,468
Acadian Asset Management LLC	[2025-06-30]	DFND	1,964,141	1,964,141
Renaissance Technologies LLC	[2025-06-30]	SOLE	1,882,860	1,882,860
Bank of America Corp /DE/	[2025-06-30]	DFND	100	1,141,713
Empirical Finance, LLC	[2025-06-30]	SOLE	800,000	800,000
FMR LLC	[2025-06-30]	DFND	464,278	464,278
Rathbones Group PLC	[2025-06-30]	SOLE	432,818	432,818
State Street Corp	[2025-06-30]	DFND	426,714	426,714
BlackRock, Inc.	[2025-06-30]	SOLE	148,909	179,087
Key Client Fiduciary Advisors LLC	[2025-06-30]	SOLE	175,555	175,555
Clear Harbor Asset Management LLC	[2025-06-30]	SOLE	145,400	145,400
Almitas Capital LLC	[2025-06-30]	SOLE	109,054	109,054
XTX Topco Ltd	[2025-06-30]	DFND	80,022	80,022
Captrust Financial Advisors	[2025-06-30]	SOLE	78,000	79,083
State of Tennessee, Department of Treasury	[2025-06-30]	SOLE	73,376	73,376
Geode Capital Management LLC	[2025-06-30]	DFND	67,032	67,032
UBS Group AG	[2025-06-30]	DFND	61,158	62,958
SEI Investments Co	[2025-06-30]	SOLE	54,824	54,824
State of New Jersey Common Pension Fund D	[2025-06-30]	SOLE	54,718	54,718
Federation des caisses Desjardins du Quebec	[2025-06-30]	DFND	53,186	53,186
Susquehanna International Group LLP	[2025-06-30]	OTR	41,785	52,085
Northern Trust Corp	[2025-06-30]	DFND	51,333	51,333
Wells Fargo & Company/MN	[2025-06-30]	DFND	0	48,900
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