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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Matrix Capital Management Company LP	[2023-03-31]	SOLE	38,974,185.0	38,974,185.0
NEA Management Company LLC	[2023-03-31]	DFND	17,079,779.0	17,079,779.0
Baillie Gifford & Co	[2023-03-31]	DFND	8,350,114.0	10,749,132.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	9,830,877.0	9,830,877.0
Baillie Gifford & Co	[2023-03-31]	SOLE	6,362,870.0	6,362,870.0
PFM Health Sciences LP	[2023-03-31]	DFND	0.0	5,992,571.0
Long Focus Capital Management LLC	[2023-03-31]	SOLE	5,435,439.0	5,435,439.0
Bank of America Corp /DE/	[2023-03-31]	DFND	0.0	5,401,710.0
Rock Springs Capital Management LP	[2023-03-31]	SOLE	2,787,845.0	2,787,845.0
Morgan Stanley	[2023-03-31]	DFND	1,758,666.0	2,252,424.0
Endurant Capital Management LP	[2023-03-31]	SOLE	1,660,835.0	1,660,835.0
FMR LLC	[2023-03-31]	DFND	1,578,783.0	1,578,783.0
Syncona Portfolio Ltd	[2023-03-31]	OTR	0.0	1,377,294.0
JPMorgan Chase & Co	[2023-03-31]	DFND	1,303,843.0	1,303,843.0
Citadel Advisors LLC	[2023-03-31]	DFND	1,139,518.0	1,139,518.0
BlackRock Inc.	[2023-03-31]	SOLE	882,527.0	883,967.0
Rathbones Group PLC	[2023-03-31]	SOLE	432,818.0	432,818.0
DAFNA Capital Management LLC	[2023-03-31]	SOLE	351,064.0	351,064.0
Key Client Fiduciary Advisors LLC	[2023-03-31]	SOLE	321,155.0	321,155.0
Acadian Asset Management LLC	[2023-03-31]	DFND	310,925.0	310,925.0
Millennium Management LLC	[2023-03-31]	SOLE	299,592.0	299,592.0
State Street Corp	[2023-03-31]	DFND	284,741.0	284,741.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	182,700.0	182,700.0
Simplify Asset Management Inc	[2023-03-31]	SOLE	150,000.0	150,000.0
Geode Capital Management LLC	[2023-03-31]	DFND	105,910.0	105,910.0
Virtu Financial LLC	[2023-03-31]	DFND	88,234.0	88,234.0
GSA Capital Partners LLP	[2023-03-31]	SOLE	48,637.0	48,637.0
Qube Research & Technologies Ltd	[2023-03-31]	SOLE	0.0	47,824.0
SEI Investments Co	[2023-03-31]	SOLE	47,409.0	47,409.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	34,000.0	34,000.0
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