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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Farallon Capital Management LLC	[2025-06-30]	OTR	5,767,466	5,767,466
Vanguard Group Inc	[2025-06-30]	SOLE	0	5,576,349
BlackRock, Inc.	[2025-06-30]	SOLE	4,668,003	4,833,760
Bellevue Group AG	[2025-06-30]	DFND	3,590,150	3,590,150
Erste Asset Management GmbH	[2025-06-30]	SOLE	2,326,489	2,326,489
Commodore Capital LP	[2025-06-30]	SOLE	2,325,000	2,325,000
State Street Corp	[2025-06-30]	DFND	1,781,985	1,951,113
Macquarie Group Ltd	[2025-06-30]	SOLE	1,850,988	1,900,596
Geode Capital Management LLC	[2025-06-30]	DFND	1,405,755	1,405,755
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	1,279,754	1,279,754
Armistice Capital LLC	[2025-06-30]	SOLE	1,168,000	1,168,000
Citadel Advisors LLC	[2025-06-30]	DFND	1,145,570	1,145,570
Paradigm Biocapital Advisors LP	[2025-06-30]	SOLE	1,142,511	1,142,511
Bank of America Corp /DE/	[2025-06-30]	DFND	10,787	1,120,308
Caligan Partners LP	[2025-06-30]	SOLE	1,071,258	1,071,258
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	1,024,811	1,046,681
JPMorgan Chase & Co	[2025-06-30]	DFND	917,690	1,027,417
Rock Springs Capital Management LP	[2025-06-30]	SOLE	989,745	989,745
Deutsche Bank AG	[2025-06-30]	DFND	883,468	921,586
Fisher Asset Management LLC	[2025-06-30]	DFND	530,666	877,540
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	791,000	791,000
TCG Crossover Management LLC	[2025-06-30]	SOLE	697,003	697,003
Marshall Wace LLP	[2025-06-30]	OTR	0	684,669
ArrowMark Colorado Holdings LLC	[2025-06-30]	SOLE	658,691	658,691
Goldman Sachs Group Inc	[2025-06-30]	DFND	647,837	648,061
SCS Capital Management LLC	[2025-06-30]	SOLE	604,085	604,085
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	594,538	596,202
OrbiMed Advisors LLC	[2025-06-30]	DFND	144,100	557,900
Northern Trust Corp	[2025-06-30]	DFND	546,208	547,490
Connor Clark & Lunn Investment Management Ltd	[2025-06-30]	SOLE	505,225	505,225
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