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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Woodline Partners LP	[2025-06-30]	SOLE	518,300	518,300
Deep Track Capital LP	[2025-06-30]	SOLE	444,110	444,110
Alyeska Investment Group LP	[2025-06-30]	SOLE	412,000	412,000
SIO Capital Management LLC	[2025-06-30]	SOLE	335,937	335,937
Tang Capital Management LLC	[2025-06-30]	OTR	0	141,131
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	140,000	140,000
Vanguard Group Inc	[2025-06-30]	SOLE	0	138,840
Readystate Asset Management LP	[2025-06-30]	SOLE	136,782	136,782
Baker Bros Advisors LP	[2025-06-30]	SOLE	83,055	83,055
HHLR Advisors Ltd	[2025-06-30]	OTR	0	76,247
Renaissance Technologies LLC	[2025-06-30]	SOLE	52,544	52,544
Geode Capital Management LLC	[2025-06-30]	DFND	34,048	34,048
LPL Financial LLC	[2025-06-30]	SOLE	0	30,100
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	25,398	25,398
Squarepoint Ops LLC	[2025-06-30]	DFND	0	18,589
Citadel Advisors LLC	[2025-06-30]	DFND	15,198	15,198
XTX Topco Ltd	[2025-06-30]	DFND	13,849	13,849
Wells Fargo & Company/MN	[2025-06-30]	DFND	0	13,770
BlackRock, Inc.	[2025-06-30]	SOLE	13,040	13,040
Millennium Management LLC	[2025-06-30]	SOLE	12,315	12,315
Two Sigma Investments LP	[2025-06-30]	SOLE	12,073	12,073
Goldman Sachs Group Inc	[2025-06-30]	DFND	10,231	10,231
Alphaquest LLC	[2025-06-30]	SOLE	5,943	5,943
Morgan Stanley	[2025-06-30]	DFND	1,403	4,005
Acadian Asset Management LLC	[2025-06-30]	DFND	3,913	3,913
UBS Group AG	[2025-06-30]	DFND	2,743	2,743
Golden State Wealth Management LLC	[2025-06-30]	SOLE	1,200	2,674
Bank of America Corp /DE/	[2025-06-30]	DFND	264	2,612
Royal Bank of Canada	[2025-06-30]	DFND	2,125	2,125
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	1,816
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