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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
NEA Management Company LLC	[2023-03-31]	DFND	6,147,260.0	6,147,260.0
BVF Inc/IL	[2023-03-31]	DFND	0.0	6,060,247.0
Logos Global Management LP	[2023-03-31]	SOLE	5,536,666.0	5,536,666.0
Rivervest Venture Management LLC	[2023-03-31]	OTR	3,349,223.0	4,887,932.0
Vivo Capital LLC	[2023-03-31]	SOLE	4,120,134.0	4,120,134.0
State Street Corp	[2023-03-31]	DFND	3,818,102.0	3,827,202.0
Deep Track Capital LP	[2023-03-31]	SOLE	3,585,000.0	3,585,000.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	2,894,317.0
Citadel Advisors LLC	[2023-03-31]	DFND	2,762,336.0	2,762,336.0
BlackRock Inc.	[2023-03-31]	SOLE	2,471,550.0	2,551,452.0
Redmile Group LLC	[2023-03-31]	SOLE	2,286,177.0	2,286,177.0
Commodore Capital LP	[2023-03-31]	SOLE	1,900,000.0	1,900,000.0
Federated Hermes Inc	[2023-03-31]	DFND	1,527,065.0	1,527,065.0
RTW Investments LP	[2023-03-31]	SOLE	1,326,608.0	1,326,608.0
Blackstone Inc.	[2023-03-31]	OTR	0.0	1,202,997.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	256,698.0	1,181,014.0
Frazier Life Sciences Management LP	[2023-03-31]	SOLE	1,112,684.0	1,112,684.0
Susquehanna International Group LLP	[2023-03-31]	DFND	945,246.0	945,246.0
Bank of America Corp /DE/	[2023-03-31]	DFND	3,959.0	899,920.0
Millennium Management LLC	[2023-03-31]	SOLE	895,365.0	895,365.0
Morgan Stanley	[2023-03-31]	DFND	791,872.0	837,621.0
Citigroup Inc	[2023-03-31]	DFND	834,899.0	834,899.0
Geode Capital Management LLC	[2023-03-31]	DFND	755,582.0	755,582.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	678,365.0	687,374.0
Platinum Investment Management Ltd	[2023-03-31]	SOLE	635,023.0	635,023.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	527,587.0	533,998.0
Qube Research & Technologies Ltd	[2023-03-31]	SOLE	0.0	531,203.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	523,977.0	523,977.0
Barclays PLC	[2023-03-31]	SOLE	460,328.0	460,328.0
Tang Capital Management LLC	[2023-03-31]	OTR	0.0	447,967.0
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