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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RTW Investments LP	[2025-06-30]	SOLE	2,542,603	2,542,603
UBS Group AG	[2025-06-30]	DFND	62,758	62,837
Unisphere Establishment	[2025-06-30]	DFND	0	49,695
Vanguard Group Inc	[2025-06-30]	SOLE	0	48,782
Geode Capital Management LLC	[2025-06-30]	DFND	39,520	39,520
BlackRock, Inc.	[2025-06-30]	SOLE	18,855	18,855
XTX Topco Ltd	[2025-06-30]	DFND	18,670	18,670
State Street Corp	[2025-06-30]	DFND	14,835	14,835
LRI Investments LLC	[2025-06-30]	SOLE	8,185	8,185
Tower Research Capital LLC (TRC)	[2025-06-30]	DFND	2,262	2,262
Citigroup Inc	[2025-06-30]	DFND	1,679	1,679
Vanguard Group Inc	[2025-06-30]	DFND	0	584
Group One Trading LLC	[2025-06-30]	SOLE	199	199
Osaic Holdings Inc	[2025-06-30]	DFND	0	100
Raymond James Financial Inc	[2025-06-30]	DFND	0	63
Bank of America Corp /DE/	[2025-06-30]	DFND	0	41
Allworth Financial LP	[2025-06-30]	SOLE	0	11
SBI Securities Co., Ltd.	[2025-06-30]	DFND	10	10
Centerpoint Advisors LLC	[2025-06-30]	SOLE	0	6
JPMorgan Chase & Co	[2025-06-30]	DFND	4	4
SignatureFD LLC	[2025-06-30]	SOLE	0	3
Harbour Investments Inc	[2025-06-30]	SOLE	0	2
Concourse Financial Group Securities Inc	[2025-06-30]	SOLE	0	0
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