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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
VR Adviser LLC	[2024-06-30]	SOLE	8,493,321.0	8,493,321.0
FMR LLC	[2024-06-30]	DFND	7,505,763.0	7,505,875.0
Wellington Management Group LLP	[2024-06-30]	DFND	0.0	3,546,949.0
BlackRock Finance, Inc.	[2024-06-30]	SOLE	2,711,302.0	2,742,549.0
RTW Investments LP	[2024-06-30]	SOLE	2,712,096.0	2,712,096.0
Braidwell LP	[2024-06-30]	SOLE	2,392,042.0	2,392,042.0
Driehaus Capital Management LLC	[2024-06-30]	SOLE	1,775,705.0	2,117,870.0
Perceptive Advisors LLC	[2024-06-30]	SOLE	2,105,636.0	2,105,636.0
Fairmount Funds Management LLC	[2024-06-30]	SOLE	2,048,647.0	2,048,647.0
RA Capital Management LP	[2024-06-30]	SOLE	1,961,863.0	1,961,863.0
Vanguard Group Inc	[2024-06-30]	SOLE	0.0	1,885,828.0
State Street Corp	[2024-06-30]	DFND	1,491,668.0	1,561,362.0
AllianceBernstein LP	[2024-06-30]	DFND	1,056,306.0	1,132,270.0
Franklin Resources Inc	[2024-06-30]	DFND	1,005,354.0	1,005,470.0
Deep Track Capital LP	[2024-06-30]	SOLE	1,000,000.0	1,000,000.0
Affinity Asset Advisors LLC	[2024-06-30]	SOLE	836,283.0	836,283.0
Woodline Partners LP	[2024-06-30]	SOLE	746,159.0	746,159.0
Geode Capital Management LLC	[2024-06-30]	DFND	740,861.0	740,861.0
Price T Rowe Associates Inc /MD/	[2024-06-30]	SOLE	730,357.0	730,357.0
Avidity Partners Management LP	[2024-06-30]	SOLE	487,000.0	487,000.0
OrbiMed Advisors LLC	[2024-06-30]	SOLE	379,130.0	379,130.0
Bank of America Corp /DE/	[2024-06-30]	DFND	5,885.0	349,556.0
Goldman Sachs Group Inc	[2024-06-30]	DFND	337,118.0	337,153.0
Paradigm Biocapital Advisors LP	[2024-06-30]	SOLE	330,000.0	330,000.0
Deerfield Management Company LP Series C	[2024-06-30]	DFND	329,000.0	329,000.0
First TURN Management LLC	[2024-06-30]	SOLE	318,327.0	318,327.0
Northern Trust Corp	[2024-06-30]	DFND	6,366.0	311,203.0
Jennison Associates LLC	[2024-06-30]	DFND	306,078.0	306,078.0
Two Sigma Investments LP	[2024-06-30]	SOLE	302,222.0	302,222.0
Commodore Capital LP	[2024-06-30]	SOLE	290,000.0	290,000.0
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