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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2023-03-31]	DFND	9,162,430.0	9,162,430.0
Frazier Life Sciences Management LP	[2023-03-31]	SOLE	8,684,232.0	8,684,232.0
BlackRock Inc.	[2023-03-31]	SOLE	4,545,792.0	4,598,272.0
State Street Corp	[2023-03-31]	DFND	3,532,521.0	3,614,781.0
Rubric Capital Management LP	[2023-03-31]	SOLE	3,500,000.0	3,500,000.0
Polar Capital Holdings Plc	[2023-03-31]	DFND	3,135,513.0	3,135,513.0
Bain Capital Life Sciences Investors, LLC	[2023-03-31]	SOLE	3,000,000.0	3,000,000.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	2,475,559.0
Marshall Wace LLP	[2023-03-31]	OTR	0.0	2,305,336.0
Jennison Associates LLC	[2023-03-31]	DFND	2,075,327.0	2,075,327.0
Holocene Advisors LP	[2023-03-31]	SOLE	2,069,177.0	2,069,177.0
OrbiMed Advisors LLC	[2023-03-31]	SOLE	1,914,479.0	1,914,479.0
GW&K Investment Management LLC	[2023-03-31]	SOLE	1,840,793.0	1,840,793.0
Pictet Asset Management Sa	[2023-03-31]	DFND	1.0	1,656,065.0
Avidity Partners Management LP	[2023-03-31]	SOLE	1,628,500.0	1,628,500.0
Bank of America Corp /DE/	[2023-03-31]	DFND	9,878.0	1,621,774.0
Franklin Resources Inc	[2023-03-31]	DFND	1,593,370.0	1,593,370.0
Barclays PLC	[2023-03-31]	SOLE	1,330,065.0	1,330,065.0
Allspring Global Investments Holdings, LLC	[2023-03-31]	DFND	302,362.0	1,114,111.0
Ameriprise Financial Inc	[2023-03-31]	DFND	0.0	854,734.0
Geode Capital Management LLC	[2023-03-31]	DFND	808,367.0	808,367.0
Woodline Partners LP	[2023-03-31]	SOLE	695,675.0	695,675.0
Suvretta Capital Management LLC	[2023-03-31]	SOLE	679,391.0	679,391.0
Pivotal Bioventure Partners Investment Advisor LLC	[2023-03-31]	DFND	0.0	569,041.0
American Century Companies Inc	[2023-03-31]	DFND	474,977.0	508,019.0
Opaleye Management Inc	[2023-03-31]	SOLE	502,000.0	502,000.0
Ensign Peak Advisors, Inc	[2023-03-31]	SOLE	486,240.0	486,240.0
Parallax Volatility Advisers LP	[2023-03-31]	SOLE	475,813.0	475,813.0
AXA Sa	[2023-03-31]	DFND	442,479.0	442,479.0
EcoR1 Capital LLC	[2023-03-31]	SOLE	415,322.0	415,322.0
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