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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
HHLR Advisors Ltd	[2024-06-30]	OTR	0.0	4,484,672.0
OrbiMed Advisors LLC	[2024-06-30]	SOLE	3,027,328.0	3,027,328.0
FMR LLC	[2024-06-30]	DFND	1,950,045.0	1,950,181.0
Octagon Capital Advisors LP	[2024-06-30]	SOLE	1,803,304.0	1,803,304.0
Suvretta Capital Management LLC	[2024-06-30]	SOLE	1,712,703.0	1,712,703.0
Sofinnova Investments Inc	[2024-06-30]	SOLE	1,696,752.0	1,696,752.0
Novo Holdings A/S	[2024-06-30]	SOLE	1,500,000.0	1,500,000.0
General Catalyst Group Management LLC	[2024-06-30]	DFND	0.0	1,494,786.0
HSG Holding Ltd	[2024-06-30]	DFND	663,308.0	663,308.0
BlackRock Finance, Inc.	[2024-06-30]	SOLE	658,187.0	663,265.0
Vanguard Group Inc	[2024-06-30]	SOLE	0.0	635,249.0
Cormorant Asset Management LP	[2024-06-30]	DFND	515,000.0	515,000.0
Perceptive Advisors LLC	[2024-06-30]	SOLE	415,000.0	415,000.0
Geode Capital Management LLC	[2024-06-30]	DFND	234,944.0	234,944.0
State Street Corp	[2024-06-30]	DFND	146,618.0	153,623.0
Woodline Partners LP	[2024-06-30]	SOLE	100,000.0	100,000.0
Alphacentric Advisors LLC	[2024-06-30]	OTR	0.0	86,000.0
Charles Schwab Investment Management Inc	[2024-06-30]	SOLE	79,727.0	79,727.0
Northern Trust Corp	[2024-06-30]	DFND	332.0	78,190.0
Ghisallo Capital Management LLC	[2024-06-30]	SOLE	50,000.0	50,000.0
Morgan Stanley	[2024-06-30]	DFND	40,133.0	41,384.0
Hidden Lake Asset Management LP	[2024-06-30]	SOLE	37,121.0	37,121.0
Bank of New York Mellon Corp	[2024-06-30]	DFND	25,465.0	29,847.0
Alps Advisors Inc	[2024-06-30]	DFND	26,139.0	26,139.0
Walleye Capital LLC	[2024-06-30]	SOLE	25,000.0	25,000.0
Nuveen Asset Management LLC	[2024-06-30]	DFND	17,570.0	17,570.0
BNP Paribas Financial Markets	[2024-06-30]	DFND	0.0	16,568.0
Vanguard Group Inc	[2024-06-30]	DFND	0.0	15,825.0
Jane Street Group LLC	[2024-06-30]	DFND	15,333.0	15,333.0
RhumbLine Advisers	[2024-06-30]	SOLE	5,629.0	12,707.0
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