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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Vanguard Group Inc	[2025-06-30]	SOLE	0	9,030,781
BlackRock, Inc.	[2025-06-30]	SOLE	7,349,281	7,535,273
Stifel Financial Corp	[2025-06-30]	DFND	6,607,324	6,607,511
Suvretta Capital Management LLC	[2025-06-30]	SOLE	5,620,271	5,620,271
Janus Henderson Group PLC	[2025-06-30]	DFND	0	5,053,528
State Street Corp	[2025-06-30]	DFND	3,239,527	3,538,163
Bellevue Group AG	[2025-06-30]	DFND	2,802,853	2,802,853
JPMorgan Chase & Co	[2025-06-30]	DFND	2,336,084	2,571,342
Millennium Management LLC	[2025-06-30]	SOLE	1,627,539	2,407,539
Caption Management LLC	[2025-06-30]	SOLE	2,143,861	2,143,861
Armistice Capital LLC	[2025-06-30]	SOLE	2,136,000	2,136,000
Geode Capital Management LLC	[2025-06-30]	DFND	2,030,919	2,030,919
FMR LLC	[2025-06-30]	DFND	1,662,701	1,664,913
Holocene Advisors LP	[2025-06-30]	SOLE	1,495,641	1,495,641
Voloridge Investment Management LLC	[2025-06-30]	SOLE	1,439,120	1,439,120
ARS Investment Partners LLC	[2025-06-30]	SOLE	151,512	1,188,126
Brown Advisory Inc	[2025-06-30]	DFND	915,991	1,121,744
Susquehanna International Group LLP	[2025-06-30]	OTR	257,877	1,095,277
Goldman Sachs Group Inc	[2025-06-30]	DFND	979,800	979,917
Norges Bank	[2025-06-30]	SOLE	902,565	902,565
Knoll Capital Management, LLC	[2025-06-30]	SOLE	895,269	895,269
Northern Trust Corp	[2025-06-30]	DFND	762,046	762,460
Morgan Stanley	[2025-06-30]	DFND	542,250	737,676
Redmile Group LLC	[2025-06-30]	SOLE	729,515	729,515
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	712,055	712,055
Logos Global Management LP	[2025-06-30]	SOLE	700,000	700,000
Oracle Investment Management Inc	[2025-06-30]	SOLE	673,166	673,166
American Century Companies Inc	[2025-06-30]	DFND	556,555	661,281
Cubist Systematic Strategies, LLC	[2025-06-30]	DFND	0	658,355
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	630,033	630,033
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