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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Northpond Ventures LLC	[2023-03-31]	SOLE	1,935,215.0	1,935,215.0
Franklin Resources Inc	[2023-03-31]	DFND	1,125,000.0	1,125,000.0
Sands Capital Ventures LLC	[2023-03-31]	SOLE	811,737.0	811,737.0
FMR LLC	[2023-03-31]	DFND	613,157.0	613,157.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	404,069.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	132,700.0	132,700.0
Geode Capital Management LLC	[2023-03-31]	DFND	131,203.0	131,203.0
Baystate Wealth Management LLC	[2023-03-31]	SOLE	105,854.0	105,854.0
Citadel Advisors LLC	[2023-03-31]	DFND	47,174.0	47,174.0
BlackRock Inc.	[2023-03-31]	SOLE	46,544.0	46,544.0
State Street Corp	[2023-03-31]	DFND	27,600.0	27,600.0
Resources Investment Advisors LLC	[2023-03-31]	SOLE	0.0	25,428.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	13,239.0	21,000.0
Northern Trust Corp	[2023-03-31]	DFND	0.0	19,617.0
Empirical Asset Management LLC	[2023-03-31]	SOLE	0.0	12,000.0
Ergoteles LLC	[2023-03-31]	SOLE	11,416.0	11,416.0
Tower Research Capital LLC (TRC)	[2023-03-31]	DFND	6,576.0	6,576.0
Vanguard Group Inc	[2023-03-31]	DFND	0.0	1,686.0
JPMorgan Chase & Co	[2023-03-31]	DFND	186.0	186.0
Quent Capital LLC	[2023-03-31]	SOLE	182.0	182.0
Wells Fargo & Company/MN	[2023-03-31]	DFND	100.0	100.0
UBS Group AG	[2023-03-31]	SOLE	10.0	10.0
Concourse Financial Group Securities Inc	[2023-03-31]	SOLE	0.0	0.0
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