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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	4,837,612	4,838,938
TPG GP A LLC	[2025-06-30]	DFND	3,967,422	3,967,422
Red Tree Management LLC	[2025-06-30]	SOLE	2,205,661	2,205,661
BlackRock, Inc.	[2025-06-30]	SOLE	1,489,103	1,519,622
Yu Fan	[2025-06-30]	SOLE	1,353,166	1,353,166
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,287,957
ABG-WTT Global Life Science Capital Partners GP Ltd	[2025-06-30]	SOLE	1,088,101	1,088,101
Novo Holdings A/S	[2025-06-30]	SOLE	900,000	900,000
TimesSquare Capital Management LLC	[2025-06-30]	SOLE	729,945	796,945
Federated Hermes Inc	[2025-06-30]	DFND	786,751	786,751
Massachusetts Financial Services Co /MA/	[2025-06-30]	SOLE	555,364	555,364
Franklin Resources Inc	[2025-06-30]	DFND	507,324	507,324
Millennium Management LLC	[2025-06-30]	SOLE	470,149	470,149
Geode Capital Management LLC	[2025-06-30]	DFND	447,936	447,936
Redmile Group LLC	[2025-06-30]	SOLE	435,239	435,239
State Street Corp	[2025-06-30]	DFND	349,224	384,350
JPMorgan Chase & Co	[2025-06-30]	DFND	342,989	380,003
Silvercrest Asset Management Group LLC	[2025-06-30]	SOLE	204,202	359,187
Peregrine Capital Management LLC	[2025-06-30]	SOLE	126,500	341,659
Lord Abbett & Co LLC	[2025-06-30]	SOLE	188,653	295,769
Next Century Growth Investors LLC	[2025-06-30]	SOLE	199,082	199,082
Northern Trust Corp	[2025-06-30]	DFND	164,777	164,777
Two Sigma Investments LP	[2025-06-30]	SOLE	164,639	164,639
RTW Investments LP	[2025-06-30]	SOLE	150,000	150,000
UBS Group AG	[2025-06-30]	DFND	149,437	149,437
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	143,831
Morgan Stanley	[2025-06-30]	DFND	127,740	128,867
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	128,048	128,048
Emerald Advisers LLC	[2025-06-30]	SOLE	95,151	125,869
Two Sigma Advisers LP	[2025-06-30]	SOLE	118,206	123,306
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