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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
MPM BioImpact LLC	[2025-06-30]	SOLE	7,648,268	7,648,268
BVF Inc/IL	[2025-06-30]	DFND	0	5,750,683
Lynx1 Capital Management LP	[2025-06-30]	OTR	0	4,400,842
BlackRock, Inc.	[2025-06-30]	SOLE	4,077,286	4,217,933
Deerfield Management Company LP	[2025-06-30]	DFND	3,855,552	3,855,552
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,952,078
Citadel Advisors LLC	[2025-06-30]	DFND	2,777,593	2,777,593
Blue Owl Capital Holdings LP	[2025-06-30]	DFND	0	2,385,972
Franklin Resources Inc	[2025-06-30]	DFND	2,228,160	2,228,160
Kynam Capital Management LP	[2025-06-30]	SOLE	2,095,998	2,095,998
OrbiMed Advisors LLC	[2025-06-30]	DFND	905,064	1,923,855
RTW Investments LP	[2025-06-30]	SOLE	1,705,960	1,705,960
State Street Corp	[2025-06-30]	DFND	1,513,474	1,607,592
VR Adviser LLC	[2025-06-30]	SOLE	1,379,965	1,379,965
Geode Capital Management LLC	[2025-06-30]	DFND	1,279,496	1,279,496
Siren, L.L.C.	[2025-06-30]	DFND	1,193,410	1,193,410
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	1,138,561	1,190,037
Nextech Invest Ltd	[2025-06-30]	SOLE	1,141,145	1,141,145
Tang Capital Management LLC	[2025-06-30]	OTR	0	1,121,138
Patient Square Capital LP	[2025-06-30]	SOLE	868,897	868,897
Caption Management LLC	[2025-06-30]	SOLE	757,527	757,527
Goldman Sachs Group Inc	[2025-06-30]	DFND	701,928	702,138
Rock Springs Capital Management LP	[2025-06-30]	SOLE	668,233	668,233
Bank of America Corp /DE/	[2025-06-30]	DFND	11,913	661,285
Marshall Wace LLP	[2025-06-30]	OTR	0	626,581
Twin Focus Capital Partners LLC	[2025-06-30]	SOLE	595,489	595,489
Foresite Capital Management VI LLC	[2025-06-30]	SOLE	594,025	594,025
Deutsche Bank AG	[2025-06-30]	DFND	0	566,781
Millennium Management LLC	[2025-06-30]	SOLE	510,828	510,828
Northern Trust Corp	[2025-06-30]	DFND	444,807	444,830
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