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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Deerfield Management Company LP Series C	[2023-03-31]	DFND	672,000.0	672,000.0
LMR Partners LLP	[2023-03-31]	SOLE	542,455.0	542,455.0
BlackRock Inc.	[2023-03-31]	SOLE	162,328.0	162,328.0
EcoR1 Capital LLC	[2023-03-31]	SOLE	100,000.0	100,000.0
CSS Llc/Il	[2023-03-31]	SOLE	99,369.0	99,369.0
Triatomic Management LP	[2023-03-31]	SOLE	65,021.0	65,021.0
Perceptive Advisors LLC	[2023-03-31]	SOLE	60,000.0	60,000.0
Castle Creek Arbitrage LLC	[2023-03-31]	SOLE	51,921.0	51,921.0
Two Sigma Investments LP	[2023-03-31]	SOLE	21,879.0	21,879.0
HRT Financial LP	[2023-03-31]	DFND	17,380.0	17,380.0
SIO Capital Management LLC	[2023-03-31]	SOLE	12,808.0	12,808.0
Bank of America Corp /DE/	[2023-03-31]	DFND	0.0	140.0
Asset Dedication LLC	[2023-03-31]	SOLE	0.0	140.0
Concourse Financial Group Securities Inc	[2023-03-31]	SOLE	0.0	0.0
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