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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
OrbiMed Advisors LLC	[2023-03-31]	DFND	18,791,422.0	22,362,850.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	6,250,000.0	6,250,000.0
Janus Henderson Group PLC	[2023-03-31]	DFND	0.0	6,004,473.0
FMR LLC	[2023-03-31]	DFND	5,681,065.0	5,681,072.0
Rock Springs Capital Management LP	[2023-03-31]	SOLE	5,513,788.0	5,513,788.0
Blackstone Inc.	[2023-03-31]	OTR	0.0	4,620,998.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	3,601,116.0
Vivo Capital LLC	[2023-03-31]	SOLE	3,556,023.0	3,556,023.0
Foresite Capital Management V, LLC	[2023-03-31]	SOLE	3,480,723.0	3,480,723.0
Braidwell LP	[2023-03-31]	SOLE	3,247,847.0	3,247,847.0
CHI Advisors LLC	[2023-03-31]	DFND	2,829,712.0	2,829,712.0
Monashee Investment Management LLC	[2023-03-31]	SOLE	2,177,042.0	2,177,042.0
Avidity Partners Management LP	[2023-03-31]	SOLE	1,825,000.0	1,825,000.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	1,557,630.0	1,557,630.0
BlackRock Inc.	[2023-03-31]	SOLE	1,526,499.0	1,540,895.0
Millennium Management LLC	[2023-03-31]	SOLE	978,403.0	978,403.0
Geode Capital Management LLC	[2023-03-31]	DFND	883,563.0	883,563.0
Susquehanna International Group LLP	[2023-03-31]	DFND	782,617.0	782,617.0
ProSight Management LP	[2023-03-31]	SOLE	678,300.0	678,300.0
Fred Alger Management LLC	[2023-03-31]	SOLE	403,062.0	403,062.0
State Street Corp	[2023-03-31]	DFND	402,313.0	402,313.0
Jane Street Group LLC	[2023-03-31]	DFND	382,385.0	382,385.0
Caxton Corp	[2023-03-31]	SOLE	211,740.0	211,740.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	198,522.0	198,522.0
Northern Trust Corp	[2023-03-31]	DFND	0.0	185,303.0
Swiss National Bank	[2023-03-31]	SOLE	163,400.0	163,400.0
Qube Research & Technologies Ltd	[2023-03-31]	SOLE	0.0	162,624.0
Morgan Stanley	[2023-03-31]	DFND	154,728.0	160,064.0
LMR Partners LLP	[2023-03-31]	SOLE	146,173.0	146,173.0
Citigroup Inc	[2023-03-31]	DFND	142,941.0	142,941.0
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