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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
OrbiMed Advisors LLC	[2025-06-30]	SOLE	15,219,994	15,219,994
Tang Capital Management LLC	[2025-06-30]	OTR	0	13,496,208
Blackstone Inc.	[2025-06-30]	OTR	0	10,025,151
Enavate Sciences GP, LLC	[2025-06-30]	SOLE	7,788,150	7,788,150
Suvretta Capital Management LLC	[2025-06-30]	SOLE	7,149,493	7,149,493
BlackRock, Inc.	[2025-06-30]	SOLE	6,276,456	6,413,133
Vivo Capital LLC	[2025-06-30]	SOLE	6,043,466	6,043,466
MPM BioImpact LLC	[2025-06-30]	SOLE	5,622,505	5,622,505
Rock Springs Capital Management LP	[2025-06-30]	SOLE	4,962,955	4,962,955
Vanguard Group Inc	[2025-06-30]	SOLE	0	4,751,179
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	4,424,868	4,424,868
FMR LLC	[2025-06-30]	DFND	4,125,794	4,134,655
Caption Management LLC	[2025-06-30]	SOLE	3,219,010	3,219,010
Blue Owl Capital Holdings LP	[2025-06-30]	DFND	0	2,591,525
Geode Capital Management LLC	[2025-06-30]	DFND	2,319,132	2,319,132
JPMorgan Chase & Co	[2025-06-30]	DFND	1,823,333	2,125,717
State Street Corp	[2025-06-30]	DFND	1,840,199	1,971,368
SilverArc Capital Management LLC	[2025-06-30]	SOLE	1,249,781	1,249,781
Millennium Management LLC	[2025-06-30]	SOLE	851,205	851,205
Northern Trust Corp	[2025-06-30]	DFND	721,056	721,056
DAFNA Capital Management LLC	[2025-06-30]	SOLE	526,660	526,660
SG Americas Securities LLC	[2025-06-30]	SOLE	372,681	372,681
Wellington Management Group LLP	[2025-06-30]	DFND	0	348,040
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	273,472	273,472
UBS Group AG	[2025-06-30]	DFND	248,526	263,526
Nuveen, LLC	[2025-06-30]	DFND	259,211	259,211
Morgan Stanley	[2025-06-30]	DFND	240,399	248,749
Barclays PLC	[2025-06-30]	SOLE	241,721	241,721
Renaissance Technologies LLC	[2025-06-30]	SOLE	224,600	224,600
Bank of New York Mellon Corp	[2025-06-30]	DFND	196,742	211,183
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