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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Johnson & Johnson	[2025-06-30]	DFND	0	4,103,430
NEA Management Company LLC	[2025-06-30]	DFND	2,026,083	2,026,083
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,055,802
BlackRock, Inc.	[2025-06-30]	SOLE	1,008,561	1,026,004
Parkman Healthcare Partners LLC	[2025-06-30]	SOLE	789,099	789,099
Balyasny Asset Management LP	[2025-06-30]	SOLE	674,685	674,685
Geode Capital Management LLC	[2025-06-30]	DFND	382,437	382,437
Silvercrest Asset Management Group LLC	[2025-06-30]	SOLE	209,375	369,831
Morgan Stanley	[2025-06-30]	DFND	352,153	368,251
Marshall Wace LLP	[2025-06-30]	OTR	0	350,080
Millennium Management LLC	[2025-06-30]	SOLE	323,158	323,158
State Street Corp	[2025-06-30]	DFND	273,006	294,736
GSA Capital Partners LLP	[2025-06-30]	SOLE	263,682	263,682
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	258,472	258,472
Archon Capital Management LLC	[2025-06-30]	SOLE	175,000	175,000
Tudor Investment Corp ET AL	[2025-06-30]	DFND	153,596	153,596
Northern Trust Corp	[2025-06-30]	DFND	146,192	146,192
Mairs & Power Inc	[2025-06-30]	SOLE	144,281	144,281
FourWorld Capital Management LLC	[2025-06-30]	SOLE	124,123	124,123
Citadel Advisors LLC	[2025-06-30]	DFND	107,320	107,320
Bank of America Corp /DE/	[2025-06-30]	DFND	11,285	89,049
UBS Group AG	[2025-06-30]	DFND	65,020	88,144
Two Sigma Investments LP	[2025-06-30]	SOLE	87,591	87,591
Goldman Sachs Group Inc	[2025-06-30]	DFND	79,796	79,856
JPMorgan Chase & Co	[2025-06-30]	DFND	66,078	73,673
Sectoral Asset Management Inc	[2025-06-30]	SOLE	73,500	73,500
Susquehanna International Group LLP	[2025-06-30]	OTR	67,850	67,850
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	53,643
Cresset Asset Management LLC	[2025-06-30]	SOLE	41,042	53,542
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	53,375	53,375
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