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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Tang Capital Management LLC	[2025-06-30]	OTR	0	1,830,097
Point72 Asset Management LP	[2025-06-30]	DFND	0	1,606,317
Deep Track Capital LP	[2025-06-30]	SOLE	1,529,987	1,529,987
Rosalind Advisors, Inc.	[2025-06-30]	SOLE	810,918	810,918
Acorn Capital Advisors LLC	[2025-06-30]	SOLE	734,394	734,394
Sphera Funds Management Ltd	[2025-06-30]	DFND	398,309	398,309
DCF Advisers, LLC	[2025-06-30]	SOLE	202,750	202,750
UBS Group AG	[2025-06-30]	DFND	178,091	179,443
Bollard Group LLC	[2025-06-30]	DFND	0	156,954
Ikarian Capital LLC	[2025-06-30]	SOLE	140,475	140,475
BlackRock, Inc.	[2025-06-30]	SOLE	127,562	127,562
Pale Fire Capital SE	[2025-06-30]	DFND	0	112,805
Advisorshares Investments LLC	[2025-06-30]	SOLE	88,383	88,383
Knott David M Jr	[2025-06-30]	DFND	66,880	66,880
Citadel Advisors LLC	[2025-06-30]	DFND	45,300	45,300
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	37,726
Fore Capital, LLC	[2025-06-30]	SOLE	31,421	31,421
PDS Planning Inc	[2025-06-30]	SOLE	0	30,344
Bank of America Corp /DE/	[2025-06-30]	DFND	1,053	29,443
Jane Street Group LLC	[2025-06-30]	DFND	26,474	26,474
Peak6 LLC	[2025-06-30]	DFND	26,284	26,284
Susquehanna International Group LLP	[2025-06-30]	OTR	24,908	24,908
Morgan Stanley	[2025-06-30]	DFND	19,169	22,821
Diametric Capital LP	[2025-06-30]	DFND	20,934	20,934
Royal Bank of Canada	[2025-06-30]	DFND	15,232	15,416
COWA LLC	[2025-06-30]	SOLE	0	13,200
Wolverine Asset Management LLC	[2025-06-30]	DFND	0	6,500
National Bank of Canada /FI/	[2025-06-30]	DFND	0	5,332
TD Waterhouse Canada Inc.	[2025-06-30]	DFND	2,753	2,753
IAG Wealth Partners LLC	[2025-06-30]	SOLE	0	2,750
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