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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	9,830,055.0
BlackRock Inc.	[2023-03-31]	SOLE	9,228,805.0	9,473,812.0
Baillie Gifford & Co	[2023-03-31]	DFND	7,985,895.0	8,159,452.0
Baillie Gifford & Co	[2023-03-31]	SOLE	7,192,659.0	7,192,659.0
Temasek Holdings (Private) Ltd	[2023-03-31]	DFND	6,895,992.0	6,895,992.0
Crestline Management LP	[2023-03-31]	SOLE	6,410,732.0	6,410,732.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	5,200,460.0
State Street Corp	[2023-03-31]	DFND	4,361,446.0	4,591,389.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	593,519.0	3,453,799.0
Flagship Pioneering Inc	[2023-03-31]	DFND	0.0	2,619,968.0
Arch Venture Management LLC	[2023-03-31]	SOLE	0.0	2,568,749.0
Capital Research Global Investors	[2023-03-31]	DFND	2,468,824.0	2,468,824.0
Geode Capital Management LLC	[2023-03-31]	DFND	2,146,172.0	2,146,172.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	1,753,848.0	1,918,129.0
Gilder Gagnon Howe & Co LLC	[2023-03-31]	DFND	0.0	1,656,397.0
Credit Suisse AG	[2023-03-31]	DFND	1,498,313.0	1,553,472.0
Citadel Advisors LLC	[2023-03-31]	DFND	1,408,725.0	1,408,725.0
Casdin Capital LLC	[2023-03-31]	SOLE	1,300,000.0	1,300,000.0
Pictet Asset Management Sa	[2023-03-31]	DFND	1.0	1,248,490.0
FMR LLC	[2023-03-31]	DFND	1,090,523.0	1,093,564.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	1,088,738.0	1,088,738.0
Federated Hermes Inc	[2023-03-31]	DFND	1,063,500.0	1,063,500.0
Northern Trust Corp	[2023-03-31]	DFND	62,322.0	1,017,812.0
Yiheng Capital Management LP	[2023-03-31]	SOLE	1,014,684.0	1,014,684.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	836,328.0	836,328.0
Artal Group S.A.	[2023-03-31]	DFND	802,899.0	802,899.0
Barclays PLC	[2023-03-31]	SOLE	656,427.0	656,427.0
T. Rowe Price Investment Management, Inc.	[2023-03-31]	SOLE	207,175.0	647,013.0
Cercano Management LLC	[2023-03-31]	SOLE	625,000.0	625,000.0
Deerfield Management Company LP Series C	[2023-03-31]	DFND	594,989.0	594,989.0
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