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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Aisling Capital Management LP	[2023-03-31]	SOLE	2,834,910.0	2,834,910.0
Qiming US Ventures Management LLC	[2023-03-31]	SOLE	2,370,142.0	2,370,142.0
BVF Inc/IL	[2023-03-31]	DFND	0.0	2,312,200.0
Cormorant Asset Management LP	[2023-03-31]	DFND	1,952,032.0	1,952,032.0
venBio Partners LLC	[2023-03-31]	SOLE	1,866,339.0	1,866,339.0
Tang Capital Management LLC	[2023-03-31]	OTR	0.0	1,400,000.0
SIO Capital Management LLC	[2023-03-31]	SOLE	876,611.0	876,611.0
Samsara Biocapital LLC	[2023-03-31]	SOLE	830,565.0	830,565.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	455,781.0
Walleye Capital LLC	[2023-03-31]	SOLE	434,448.0	434,448.0
Kennedy Capital Management LLC	[2023-03-31]	SOLE	149,649.0	149,649.0
Morgan Stanley	[2023-03-31]	DFND	148,450.0	148,450.0
Geode Capital Management LLC	[2023-03-31]	DFND	130,380.0	130,380.0
Two Sigma Investments LP	[2023-03-31]	SOLE	73,958.0	73,958.0
Caxton Corp	[2023-03-31]	SOLE	68,324.0	68,324.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	56,500.0	56,500.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	51,500.0	51,500.0
Annandale Capital LLC	[2023-03-31]	DFND	0.0	50,000.0
State Street Corp	[2023-03-31]	DFND	42,100.0	42,100.0
BlackRock Inc.	[2023-03-31]	SOLE	32,751.0	32,751.0
Virtu Financial LLC	[2023-03-31]	DFND	27,286.0	27,286.0
JPMorgan Chase & Co	[2023-03-31]	DFND	22,347.0	22,347.0
Northern Trust Corp	[2023-03-31]	DFND	0.0	14,991.0
Jane Street Group LLC	[2023-03-31]	DFND	10,449.0	10,449.0
UBS Group AG	[2023-03-31]	DFND	0.0	100.0
Wells Fargo & Company/MN	[2023-03-31]	DFND	92.0	92.0
Concourse Financial Group Securities Inc	[2023-03-31]	SOLE	0.0	0.0
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