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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BVF Inc/IL	[2025-06-30]	DFND	0	8,748,629
Tang Capital Management LLC	[2025-06-30]	OTR	0	4,300,000
BML Capital Management LLC	[2025-06-30]	SOLE	0	4,221,546
Morgan Stanley	[2025-06-30]	DFND	4,174,170	4,209,670
Soleus Capital Management LP	[2025-06-30]	SOLE	2,262,026	2,262,026
Opaleye Management Inc	[2025-06-30]	SOLE	2,209,998	2,209,998
Pfizer Inc	[2025-06-30]	SOLE	1,675,000	1,675,000
Bank of America Corp /DE/	[2025-06-30]	DFND	0	627,930
Aldebaran Capital LLC	[2025-06-30]	SOLE	578,939	578,939
Susquehanna International Group LLP	[2025-06-30]	OTR	0	405,800
DLD Asset Management LP	[2025-06-30]	SOLE	314,968	314,968
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	271,195
Two Sigma Advisers LP	[2025-06-30]	SOLE	250,900	260,800
Two Sigma Investments LP	[2025-06-30]	SOLE	222,327	222,327
LMR Partners LLP	[2025-06-30]	SOLE	200,000	200,000
Jane Street Group LLC	[2025-06-30]	DFND	152,107	192,707
JPMorgan Chase & Co	[2025-06-30]	DFND	189,094	189,094
Rangeley Capital LLC	[2025-06-30]	SOLE	170,000	170,000
Citadel Advisors LLC	[2025-06-30]	DFND	145,639	145,639
Group One Trading LLC	[2025-06-30]	SOLE	83,823	83,823
Magnus Financial Group LLC	[2025-06-30]	SOLE	0	55,206
Adar1 Capital Management LLC	[2025-06-30]	SOLE	50,000	50,000
American Century Companies Inc	[2025-06-30]	DFND	46,373	46,373
XTX Topco Ltd	[2025-06-30]	DFND	42,173	42,173
Lepercq de Neuflize Asset Management LLC	[2025-06-30]	SOLE	33,700	33,700
Shay Capital LLC	[2025-06-30]	SOLE	24,348	24,348
Geode Capital Management LLC	[2025-06-30]	DFND	23,840	23,840
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	14,343	14,343
UBS Group AG	[2025-06-30]	DFND	12,021	12,021
BlackRock, Inc.	[2025-06-30]	SOLE	7,074	7,074
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