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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Softbank Group Corp	[2023-03-31]	DFND	5,681,818.0	5,681,818.0
Platinum Investment Management Ltd	[2023-03-31]	SOLE	3,950,064.0	3,986,221.0
BlackRock Inc.	[2023-03-31]	SOLE	3,887,200.0	3,887,200.0
Baillie Gifford & Co	[2023-03-31]	DFND	1,880,576.0	3,527,397.0
Laurion Capital Management LP	[2023-03-31]	SOLE	3,131,608.0	3,131,608.0
Baillie Gifford & Co	[2023-03-31]	SOLE	930,650.0	1,714,683.0
Bill & Melinda Gates Foundation	[2023-03-31]	SOLE	1,590,909.0	1,590,909.0
MIC Capital Management UK LLP	[2023-03-31]	SOLE	1,542,600.0	1,542,600.0
Marshall Wace LLP	[2023-03-31]	OTR	0.0	1,425,148.0
Pictet Asset Management Sa	[2023-03-31]	DFND	0.0	884,056.0
Nan Fung Group Holdings Ltd	[2023-03-31]	DFND	859,892.0	859,892.0
Pivotal Bioventure Partners Investment Advisor LLC	[2023-03-31]	DFND	0.0	772,285.0
Woodline Partners LP	[2023-03-31]	SOLE	622,658.0	622,658.0
Citigroup Inc	[2023-03-31]	DFND	580,234.0	580,234.0
Wells Fargo & Company/MN	[2023-03-31]	DFND	0.0	284,716.0
Legal & General Group Plc	[2023-03-31]	DFND	235,699.0	235,699.0
Casdin Capital LLC	[2023-03-31]	SOLE	213,900.0	213,900.0
Vontobel Holding Ltd.	[2023-03-31]	DFND	211,803.0	211,803.0
Mitsubishi UFJ Trust & Banking Corp	[2023-03-31]	SOLE	211,400.0	211,400.0
Sectoral Asset Management Inc	[2023-03-31]	SOLE	210,303.0	210,303.0
Integral Health Asset Management LLC	[2023-03-31]	SOLE	152,000.0	152,000.0
Russell Investments Group, Ltd.	[2023-03-31]	DFND	126,085.0	126,085.0
Alberta Investment Management Corp	[2023-03-31]	SOLE	104,620.0	104,620.0
Susquehanna International Group LLP	[2023-03-31]	DFND	35,857.0	96,157.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	46,486.0	84,600.0
Morgan Stanley	[2023-03-31]	DFND	53,459.0	79,721.0
Strategic Vision Investment Ltd	[2023-03-31]	SOLE	63,689.0	63,689.0
Citadel Advisors LLC	[2023-03-31]	DFND	59,265.0	59,265.0
Values First Advisors Inc	[2023-03-31]	SOLE	0.0	35,423.0
State Street Corp	[2023-03-31]	DFND	28,658.0	28,658.0
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