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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Flagship Pioneering Inc	[2025-06-30]	DFND	0	12,674,120
FMR LLC	[2025-06-30]	DFND	5,532,845	5,534,516
BVF Inc/IL	[2025-06-30]	DFND	0	5,302,000
Deerfield Management Company LP	[2025-06-30]	DFND	3,255,514	3,255,514
Raymond James Financial Inc	[2025-06-30]	DFND	0	2,367,292
BlackRock, Inc.	[2025-06-30]	SOLE	2,185,926	2,229,133
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,845,605
Euclidean Capital LLC	[2025-06-30]	SOLE	1,573,761	1,573,761
Geode Capital Management LLC	[2025-06-30]	DFND	807,674	807,674
Siren, L.L.C.	[2025-06-30]	DFND	720,720	720,720
Point72 Asset Management LP	[2025-06-30]	DFND	0	668,719
State Street Corp	[2025-06-30]	DFND	513,876	543,647
Alphabet Inc.	[2025-06-30]	DFND	0	500,901
Birchview Capital LP	[2025-06-30]	SOLE	310,930	310,930
DAFNA Capital Management LLC	[2025-06-30]	SOLE	300,452	300,452
Northern Trust Corp	[2025-06-30]	DFND	281,638	281,638
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	190,794	192,663
Cantor Fitzgerald L P	[2025-06-30]	DFND	0	150,000
SIO Capital Management LLC	[2025-06-30]	SOLE	122,889	122,889
Wellington Management Group LLP	[2025-06-30]	DFND	0	118,342
Ameriprise Financial Inc	[2025-06-30]	DFND	0	112,237
SCS Capital Management LLC	[2025-06-30]	SOLE	106,980	106,980
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	98,177	98,177
Morgan Stanley	[2025-06-30]	DFND	51,180	79,553
Bank of New York Mellon Corp	[2025-06-30]	DFND	68,516	72,437
Barclays PLC	[2025-06-30]	SOLE	70,814	70,814
PanAgora Asset Management Inc	[2025-06-30]	SOLE	9,958	65,337
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	64,100	64,100
Renaissance Technologies LLC	[2025-06-30]	SOLE	62,636	62,636
State of Wisconsin Investment Board	[2025-06-30]	SOLE	61,544	61,544
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