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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Gilead Sciences Inc	[2025-06-30]	DFND	16,707,477	16,707,477
Tang Capital Management LLC	[2025-06-30]	OTR	0	3,990,111
Madison Avenue Partners LP	[2025-06-30]	SOLE	1,877,011	1,877,011
ProSight Management LP	[2025-06-30]	SOLE	1,773,649	1,773,649
FMR LLC	[2025-06-30]	DFND	1,542,855	1,547,028
EcoR1 Capital LLC	[2025-06-30]	SOLE	1,036,945	1,036,945
Hudson Bay Capital Management LP	[2025-06-30]	SOLE	798,400	798,400
Caption Management LLC	[2025-06-30]	SOLE	591,100	591,100
Segall Bryant & Hamill LLC	[2025-06-30]	SOLE	326,033	501,077
Renaissance Technologies LLC	[2025-06-30]	SOLE	464,700	464,700
DME Capital Management LP	[2025-06-30]	SOLE	376,063	376,063
Point72 Asset Management LP	[2025-06-30]	DFND	0	341,500
LMR Partners LLP	[2025-06-30]	SOLE	283,400	283,400
UBS Group AG	[2025-06-30]	DFND	238,434	238,524
BlackRock, Inc.	[2025-06-30]	SOLE	223,753	226,056
Millennium Management LLC	[2025-06-30]	SOLE	190,709	190,709
Centiva Capital LP	[2025-06-30]	SOLE	169,905	169,905
Susquehanna International Group LLP	[2025-06-30]	OTR	15,183	165,283
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	153,185	153,185
PRIMECAP Management Co/CA/	[2025-06-30]	SOLE	143,310	143,310
DAFNA Capital Management LLC	[2025-06-30]	SOLE	130,175	130,175
Norges Bank	[2025-06-30]	SOLE	120,000	120,000
DME Capital Management LP	[2025-06-30]	OTR	106,683	106,683
Voloridge Investment Management LLC	[2025-06-30]	SOLE	85,401	85,401
Royal Bank of Canada	[2025-06-30]	DFND	80,676	80,862
Optiver Holding B.V.	[2025-06-30]	DFND	0	78,929
Tower Research Capital LLC (TRC)	[2025-06-30]	OTR	78,591	78,591
Morgan Stanley	[2025-06-30]	DFND	52,815	66,164
Citadel Advisors LLC	[2025-06-30]	DFND	60,907	60,907
Goldman Sachs Group Inc	[2025-06-30]	DFND	56,731	56,731
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