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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
NEA Management Company LLC	[2023-03-31]	DFND	7,692,298.0	7,692,298.0
FMR LLC	[2023-03-31]	DFND	6,420,538.0	6,421,039.0
Avoro Capital Advisors LLC	[2023-03-31]	SOLE	4,325,000.0	4,325,000.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	679,365.0	3,688,027.0
BlackRock Inc.	[2023-03-31]	SOLE	3,554,086.0	3,609,421.0
Cormorant Asset Management LP	[2023-03-31]	DFND	2,893,717.0	2,893,717.0
T. Rowe Price Investment Management, Inc.	[2023-03-31]	SOLE	516,209.0	1,717,065.0
Aisling Capital Management LP	[2023-03-31]	SOLE	1,472,331.0	1,472,331.0
Alphabet Inc.	[2023-03-31]	DFND	0.0	1,464,015.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,405,955.0
Citadel Advisors LLC	[2023-03-31]	DFND	812,901.0	812,901.0
Geode Capital Management LLC	[2023-03-31]	DFND	583,089.0	583,089.0
State Street Corp	[2023-03-31]	DFND	497,646.0	530,746.0
Casdin Capital LLC	[2023-03-31]	SOLE	510,882.0	510,882.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	375,095.0	375,095.0
ExodusPoint Capital Management LP	[2023-03-31]	SOLE	261,593.0	261,593.0
Northern Trust Corp	[2023-03-31]	DFND	7,048.0	250,527.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	224,386.0	224,386.0
TD Asset Management Inc	[2023-03-31]	SOLE	140,854.0	140,854.0
Millennium Management LLC	[2023-03-31]	SOLE	117,094.0	117,094.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	111,649.0	111,649.0
Manufacturers Life Insurance Company the	[2023-03-31]	DFND	103,250.0	103,250.0
UBS OConnor LLC	[2023-03-31]	DFND	95,528.0	95,528.0
Voya Investment Management LLC	[2023-03-31]	DFND	0.0	92,328.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	76,087.0	88,455.0
Sarasin & Partners LLP	[2023-03-31]	SOLE	65,081.0	65,081.0
Bank of America Corp /DE/	[2023-03-31]	DFND	6,282.0	49,922.0
RhumbLine Advisers	[2023-03-31]	SOLE	20,125.0	46,173.0
Swiss National Bank	[2023-03-31]	SOLE	41,800.0	41,800.0
Vanguard Group Inc	[2023-03-31]	DFND	0.0	41,479.0
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