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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Wellington Management Group LLP	[2025-06-30]	DFND	0	6,875,769
Deep Track Capital LP	[2025-06-30]	SOLE	5,133,917	5,133,917
FMR LLC	[2025-06-30]	DFND	4,914,965	4,914,965
Janus Henderson Group PLC	[2025-06-30]	DFND	0	4,573,006
Baker Bros Advisors LP	[2025-06-30]	SOLE	2,508,767	2,508,767
BVF Inc/IL	[2025-06-30]	DFND	0	1,771,417
Capital International Investors	[2025-06-30]	DFND	1,618,876	1,618,876
Ameriprise Financial Inc	[2025-06-30]	DFND	0	1,588,198
RA Capital Management LP	[2025-06-30]	SOLE	1,517,418	1,517,418
Citadel Advisors LLC	[2025-06-30]	DFND	1,498,779	1,498,779
Casdin Capital LLC	[2025-06-30]	SOLE	1,225,000	1,225,000
Millennium Management LLC	[2025-06-30]	SOLE	1,220,055	1,220,055
Vestal Point Capital LP	[2025-06-30]	SOLE	1,200,000	1,200,000
OrbiMed Advisors LLC	[2025-06-30]	DFND	220,300	1,199,300
Rock Springs Capital Management LP	[2025-06-30]	SOLE	1,135,879	1,135,879
TCG Crossover Management LLC	[2025-06-30]	SOLE	1,063,000	1,063,000
Morgan Stanley	[2025-06-30]	DFND	656,515	917,346
Principal Financial Group Inc	[2025-06-30]	DFND	853,202	853,202
Logos Global Management LP	[2025-06-30]	SOLE	850,000	850,000
Franklin Resources Inc	[2025-06-30]	DFND	741,783	741,783
Driehaus Capital Management LLC	[2025-06-30]	SOLE	587,571	672,792
Catalio Capital Management LP	[2025-06-30]	SOLE	670,575	670,575
American Century Companies Inc	[2025-06-30]	DFND	351,833	491,193
Federated Hermes Inc	[2025-06-30]	DFND	468,300	468,300
Pacific Heights Asset Management LLC	[2025-06-30]	SOLE	460,000	460,000
Monashee Investment Management LLC	[2025-06-30]	SOLE	430,000	430,000
Invesco Ltd.	[2025-06-30]	DFND	0	424,548
Aberdeen Group plc	[2025-06-30]	DFND	401,624	401,624
Deerfield Management Company LP	[2025-06-30]	DFND	373,407	373,407
Price T Rowe Associates Inc /MD/	[2025-06-30]	SOLE	352,868	352,868
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