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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	7,679,867.0
Redmile Group LLC	[2023-03-31]	SOLE	6,926,926.0	6,926,926.0
Frazier Life Sciences Management LP	[2023-03-31]	SOLE	5,162,348.0	5,162,348.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	3,629,063.0
Versant Venture Management LLC	[2023-03-31]	OTR	0.0	3,561,150.0
Balyasny Asset Management LP	[2023-03-31]	SOLE	2,373,030.0	2,373,030.0
BlackRock Inc.	[2023-03-31]	SOLE	1,897,480.0	1,932,655.0
Morgan Stanley	[2023-03-31]	DFND	1,815,011.0	1,832,625.0
Assenagon Asset Management S.A.	[2023-03-31]	SOLE	1,538,368.0	1,538,368.0
Bank of America Corp /DE/	[2023-03-31]	DFND	40,000.0	1,060,238.0
FMR LLC	[2023-03-31]	DFND	789,449.0	798,513.0
Geode Capital Management LLC	[2023-03-31]	DFND	744,580.0	744,580.0
Citadel Advisors LLC	[2023-03-31]	DFND	731,265.0	731,265.0
Millennium Management LLC	[2023-03-31]	SOLE	711,218.0	711,218.0
Susquehanna International Group LLP	[2023-03-31]	DFND	644,197.0	684,597.0
Palo Alto Investors LP	[2023-03-31]	SOLE	666,127.0	666,127.0
Endurant Capital Management LP	[2023-03-31]	SOLE	540,657.0	540,657.0
Marshall Wace LLP	[2023-03-31]	OTR	0.0	422,045.0
Jane Street Group LLC	[2023-03-31]	DFND	400,609.0	400,609.0
Jacobs Levy Equity Management Inc	[2023-03-31]	SOLE	223,485.0	296,312.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	248,376.0	286,771.0
HRT Financial LP	[2023-03-31]	DFND	285,377.0	285,377.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	275,765.0	275,765.0
State Street Corp	[2023-03-31]	DFND	273,330.0	273,330.0
Boothbay Fund Management LLC	[2023-03-31]	OTR	0.0	248,854.0
UBS Group AG	[2023-03-31]	DFND	0.0	212,933.0
Qube Research & Technologies Ltd	[2023-03-31]	SOLE	0.0	212,837.0
Group One Trading LP	[2023-03-31]	SOLE	187,425.0	187,425.0
Captrust Financial Advisors	[2023-03-31]	SOLE	186,934.0	186,934.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	182,900.0	182,900.0
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