Casdin Capital LLC

Item 5:           Fees and Compensation

This brochure is delivered to qualified purchasers and therefore does not contain our advisory service fee
schedule. The fees applicable to our client funds are set forth in detail in their respective governing
documents and each fund’s private placement memorandum together with the relevant supplements
thereto, which set forth the relevant asset-based and performance-based fee percentages applicable to
investors. We only offer interest in our client funds to investors that qualify as accredited investors and
qualified purchasers as defined in the Investment Company Act of 1940, as amended.

As compensation for our services to our client funds, the Firm, or an affiliate of the Firm, typically
receives, as set forth in the respective private placement memorandum and/or the relevant supplement
thereto, at a fund level, a management fee based on a percentage of assets we manage and a
performance-based fee (i.e., a “performance allocation” or “carried interest”) based on capital
appreciation.

For the Hedge Funds, the management fee is generally calculated based on the aggregate capital account
balances of applicable investors in a fund; however, the management fee will be calculated based on
the lesser of historical cost or the estimated fair market value for certain non-marketable or illiquid
investments in the Hedge Funds (“Special Situation Investments” as further described in Casdin
Partners’ and Casdin Offshore’s private placement memorandum). Management fees are calculated and
payable quarterly in advance. Management fees are deducted directly from our client funds’ investors’
accounts.

For PE Funds, the management fee is generally calculated based on the invested capital attributable to
applicable investors, as determined under the applicable fund governing documents. Management fees are
calculated and payable quarterly in advance. Management fees are generally payable out of amounts
otherwise distributable to investors and, as applicable, through drawdowns of commitments, and are
reflected in the applicable investors’ capital accounts.

For investors in the Hedge Funds, we typically structure our performance allocation as a debit against
the capital accounts of the limited partners of a fund and a credit to the capital account of the General
Partner. The performance allocation is subject to a loss carryforward requirement or “high water mark”
(i.e., we only receive a performance allocation when an investor’s account value for the year has
recovered any losses from prior years, reduced proportionately by any withdrawals or redemptions an
investor makes). Each client fund’s net profits are calculated net of the management fee, but before the
performance allocation. Net profits include unrealized appreciation or depreciation of marketable
positions, as well as any dividends or distributions. The Master Fund’s investors do not pay a
performance allocation on any unrealized appreciation on Special Situation Investments but may pay a
performance allocation upon the realization of profits related to such Special Situation Investments.
Certain investors who hold a particular class or tranche that is no longer offered in Casdin Partners and
Casdin Offshore respectively, are subject to a “hurdle rate” equal to the 12-month trailing average for five-
year U.S. Treasury Bills issued prior to the last day of the relevant performance period. The performance
allocation is applied only to net profits of a particular limited partner or shareholder for the year in
excess of the “hurdle rate.” The “hurdle rate” is capped at 3% per annum.

Investors in the PE Funds will pay carried interest based on realized profits. The carried interest will
generally occur after an investor in the PE Funds has received a return of all of its capital contributions.

We waive the portion of the management fee and incentive allocation or carried interest that is allocable
to investors who are Casdin affiliates, Casdin employees, members of their immediate family and their
lineal descendants, trusts or other entities established for their benefit and family or other foundations
established by such persons. Our fees are generally non-negotiable, but in the General Partner’s sole
discretion, the management fee and performance allocation may be waived, reduced or calculated
differently with respect to certain investors in our client funds.

Casdin Capital, LLC                                                                   Form ADV Part 2A

Each of our client funds bear various costs, fees and expenses in addition to the compensation payable to
the Firm or an affiliate of the Firm. Although we set forth enumerated lists below, all investors in our
client funds and prospective investors should review the private placement memorandum of their
respective fund (including any relevant supplements) and other governing documents for each applicable
client, which may discuss additional costs, fees and expenses not discussed below.

Our client funds, and consequently the investors in our client funds, generally incur the following
expenses:

     •   offering, organizational and reorganizational expenses (including legal and accounting fees,
         printing costs, travel, “blue sky” filing fees and expenses and out-of-pocket expenses)

     •   expenses related to the research, due diligence and monitoring of actual and prospective
         investments (whether or not consummated) and the consummation of investments,
         including, without limitation, (i) third-party investment sourcing fees; (ii) fees and expenses
         related to obtaining research and market data (including, without limitation, travel, lodging,
         meal expense, any information technology hardware, software or other technology
         incorporated into the cost of obtaining such research and market data); (iii) due diligence
...

Item 7:            Types of Clients

Each of our client funds is a pooled investment vehicle, or more specifically, a private investment fund,
the securities of which are offered to certain qualified investors on a private placement basis. Any initial
and additional subscription minimums are disclosed in such client fund’s governing documents. The Firm,
however, is not precluded from advising types of client funds that are not listed above.

Investment advice is provided directly to such pooled investment vehicles and not individually to the
investors. Investors in such pooled investment vehicles may include, but are not limited to, high net
worth individuals, family offices, fund of hedge funds, endowments, foundations, trusts, charitable
organizations, insurance companies, pension plans, sovereign wealth funds and corporate or business

Casdin Capital, LLC                                                                        Form ADV Part 2A

entities.

This brochure is not an offer to invest in any of our client funds.