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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Cormorant Asset Management LP	[2025-06-30]	DFND	2,909,000	2,909,000
BlackRock, Inc.	[2025-06-30]	SOLE	1,498,865	1,498,865
Citadel Advisors LLC	[2025-06-30]	DFND	1,427,201	1,427,201
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	1,400,000	1,400,000
Millennium Management LLC	[2025-06-30]	SOLE	897,251	897,251
Sculptor Capital LP	[2025-06-30]	DFND	800,000	800,000
SilverArc Capital Management LLC	[2025-06-30]	SOLE	613,393	613,393
Farallon Capital Management LLC	[2025-06-30]	OTR	600,000	600,000
Harraden Circle Investments LLC	[2025-06-30]	SOLE	569,831	569,831
Berkley W R Corp	[2025-06-30]	SOLE	445,195	445,195
Toronto Dominion Bank	[2025-06-30]	DFND	0	444,377
Adar1 Capital Management LLC	[2025-06-30]	SOLE	442,615	442,615
Perceptive Advisors LLC	[2025-06-30]	SOLE	398,000	398,000
Decagon Asset Management LLP	[2025-06-30]	SOLE	348,223	348,223
Stempoint Capital LP	[2025-06-30]	SOLE	315,812	315,812
Laurion Capital Management LP	[2025-06-30]	SOLE	300,000	300,000
Shaolin Capital Management LLC	[2025-06-30]	SOLE	292,338	292,338
Octagon Capital Advisors LP	[2025-06-30]	SOLE	250,000	250,000
JPMorgan Chase & Co	[2025-06-30]	DFND	210,125	210,125
Clear Street LLC	[2025-06-30]	SOLE	205,666	205,666
Creative Planning	[2025-06-30]	SOLE	0	200,000
Acuta Capital Partners LLC	[2025-06-30]	SOLE	187,257	187,257
Wellington Management Group LLP	[2025-06-30]	DFND	0	184,590
TD Asset Management Inc	[2025-06-30]	SOLE	144,772	144,772
Hudson Bay Capital Management LP	[2025-06-30]	SOLE	108,300	108,300
Woodline Partners LP	[2025-06-30]	SOLE	103,247	103,247
K2 Principal Fund LP	[2025-06-30]	SOLE	100,000	100,000
Moore Capital Management LP	[2025-06-30]	SOLE	100,000	100,000
UBS Group AG	[2025-06-30]	DFND	68,534	68,534
Great Point Partners LLC	[2025-06-30]	SOLE	0	29,381
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