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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Valor Management LLC	[2023-03-31]	SOLE	11,218,033.0	11,218,033.0
FMR LLC	[2023-03-31]	DFND	5,590,969.0	5,591,575.0
BlackRock Inc.	[2023-03-31]	SOLE	4,876,554.0	4,959,187.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	3,463,958.0
Vivo Capital LLC	[2023-03-31]	SOLE	2,606,247.0	2,606,247.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	1,415,000.0	1,415,000.0
State Street Corp	[2023-03-31]	DFND	998,610.0	1,043,597.0
venBio Partners LLC	[2023-03-31]	SOLE	1,035,396.0	1,035,396.0
Invesco Ltd.	[2023-03-31]	DFND	0.0	954,331.0
Macquarie Group Ltd	[2023-03-31]	SOLE	828,669.0	828,669.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	728,449.0	779,040.0
Neumeier Poma Investment Counsel LLC	[2023-03-31]	SOLE	352,070.0	678,715.0
abrdn plc	[2023-03-31]	DFND	629,660.0	629,660.0
American Century Companies Inc	[2023-03-31]	DFND	338,969.0	614,841.0
Bellevue Group AG	[2023-03-31]	DFND	598,046.0	598,046.0
Citadel Advisors LLC	[2023-03-31]	DFND	576,207.0	576,207.0
Geode Capital Management LLC	[2023-03-31]	DFND	573,625.0	573,625.0
International Biotechnology Trust PLC	[2023-03-31]	SOLE	570,500.0	570,500.0
Morgan Stanley	[2023-03-31]	DFND	530,303.0	562,072.0
Millennium Management LLC	[2023-03-31]	SOLE	443,032.0	483,032.0
Balyasny Asset Management LP	[2023-03-31]	SOLE	469,723.0	469,723.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	464,964.0	465,800.0
Ashford Capital Management Inc	[2023-03-31]	SOLE	445,418.0	445,418.0
Massachusetts Financial Services Co /MA/	[2023-03-31]	SOLE	410,937.0	410,937.0
Great Lakes Advisors LLC	[2023-03-31]	SOLE	374,195.0	406,180.0
Jacobs Levy Equity Management Inc	[2023-03-31]	SOLE	342,886.0	376,386.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	369,128.0	369,128.0
Nan Fung Group Holdings Ltd	[2023-03-31]	DFND	368,665.0	368,665.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	318,500.0	363,900.0
Royce & Associates LP	[2023-03-31]	SOLE	332,329.0	332,329.0
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