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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Baker Bros Advisors LP	[2025-06-30]	SOLE	4,096,210	4,096,210
Siren, L.L.C.	[2025-06-30]	DFND	3,255,826	3,255,826
Redmile Group LLC	[2025-06-30]	SOLE	2,952,131	2,952,131
Sanofi	[2025-06-30]	SOLE	1,438,975	1,438,975
Goldman Sachs Group Inc	[2025-06-30]	DFND	855,286	855,286
Vanguard Group Inc	[2025-06-30]	SOLE	0	760,889
BlackRock, Inc.	[2025-06-30]	SOLE	382,484	385,474
Millennium Management LLC	[2025-06-30]	SOLE	275,112	275,112
Geode Capital Management LLC	[2025-06-30]	DFND	213,273	213,273
Jane Street Group LLC	[2025-06-30]	DFND	180,985	180,985
AQR Capital Management LLC	[2025-06-30]	DFND	159,207	159,207
Renaissance Technologies LLC	[2025-06-30]	SOLE	117,734	117,734
Northern Trust Corp	[2025-06-30]	DFND	107,568	107,568
Two Sigma Investments LP	[2025-06-30]	SOLE	104,290	104,290
Eagle Bay Advisors LLC	[2025-06-30]	SOLE	0	99,635
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	89,705	89,705
Two Sigma Advisers LP	[2025-06-30]	SOLE	79,300	82,700
Susquehanna International Group LLP	[2025-06-30]	OTR	80,311	80,311
State Street Corp	[2025-06-30]	DFND	75,913	75,913
Woodline Partners LP	[2025-06-30]	SOLE	69,576	69,576
Verition Fund Management LLC	[2025-06-30]	SOLE	48,962	48,962
Acadian Asset Management LLC	[2025-06-30]	DFND	45,253	45,253
Marshall Wace LLP	[2025-06-30]	OTR	0	44,287
Royal Bank of Canada	[2025-06-30]	DFND	40,039	40,039
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	39,340	39,340
Price T Rowe Associates Inc /MD/	[2025-06-30]	DFND	35,210	35,210
IEQ Capital LLC	[2025-06-30]	OTR	0	27,410
XTX Topco Ltd	[2025-06-30]	DFND	26,472	26,472
Morgan Stanley	[2025-06-30]	DFND	20,100	20,100
Savant Capital LLC	[2025-06-30]	SOLE	0	19,946
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