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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Atlas Venture Life Science Advisors LLC	[2023-03-31]	SOLE	5,018,178.0	5,018,178.0
FMR LLC	[2023-03-31]	DFND	3,313,385.0	3,313,385.0
OrbiMed Advisors LLC	[2023-03-31]	DFND	2,189,111.0	3,186,166.0
BVF Inc/IL	[2023-03-31]	DFND	0.0	3,169,164.0
Omega Fund Management LLC	[2023-03-31]	SOLE	2,249,123.0	2,249,123.0
CHI Advisors LLC	[2023-03-31]	DFND	1,660,872.0	1,660,872.0
Verition Fund Management LLC	[2023-03-31]	SOLE	1,595,941.0	1,595,941.0
Artal Group S.A.	[2023-03-31]	DFND	1,549,513.0	1,549,513.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	991,356.0
Laurion Capital Management LP	[2023-03-31]	SOLE	529,000.0	529,000.0
BlackRock Inc.	[2023-03-31]	SOLE	307,234.0	307,234.0
Geode Capital Management LLC	[2023-03-31]	DFND	242,720.0	242,720.0
Barclays PLC	[2023-03-31]	SOLE	198,041.0	198,041.0
Citadel Advisors LLC	[2023-03-31]	DFND	180,097.0	180,097.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	114,650.0	114,650.0
DAFNA Capital Management LLC	[2023-03-31]	SOLE	112,936.0	112,936.0
Millennium Management LLC	[2023-03-31]	SOLE	108,880.0	108,880.0
Ensign Peak Advisors, Inc	[2023-03-31]	SOLE	90,310.0	90,310.0
State Street Corp	[2023-03-31]	DFND	59,953.0	59,953.0
Susquehanna International Group LLP	[2023-03-31]	DFND	39,732.0	39,732.0
Cornercap Investment Counsel Inc	[2023-03-31]	SOLE	24,729.0	39,461.0
Jane Street Group LLC	[2023-03-31]	DFND	38,318.0	38,318.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	35,192.0	35,192.0
Northern Trust Corp	[2023-03-31]	DFND	45.0	30,790.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	29,542.0	29,542.0
Jacobs Levy Equity Management Inc	[2023-03-31]	SOLE	18,144.0	18,144.0
Morgan Stanley	[2023-03-31]	DFND	13,443.0	13,488.0
Acadian Asset Management LLC	[2023-03-31]	DFND	13,301.0	13,301.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	12,066.0	12,066.0
Dimensional Fund Advisors LP	[2023-03-31]	DFND	0.0	11,897.0
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