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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RTW Investments LP	[2025-06-30]	SOLE	4,869,798	4,869,798
FMR LLC	[2025-06-30]	DFND	4,851,826	4,855,772
Wellington Management Group LLP	[2025-06-30]	DFND	0	4,213,575
PRIMECAP Management Co/CA/	[2025-06-30]	SOLE	3,745,814	3,771,474
Bellevue Group AG	[2025-06-30]	DFND	2,441,830	2,441,830
Baker Bros Advisors LP	[2025-06-30]	SOLE	2,322,656	2,322,656
Tang Capital Management LLC	[2025-06-30]	OTR	0	2,105,608
Deep Track Capital LP	[2025-06-30]	SOLE	1,800,000	1,800,000
BVF Inc/IL	[2025-06-30]	DFND	0	1,024,288
Kynam Capital Management LP	[2025-06-30]	SOLE	976,267	976,267
Caption Management LLC	[2025-06-30]	SOLE	866,703	866,703
Citigroup Inc	[2025-06-30]	DFND	843,701	843,701
Point72 Asset Management LP	[2025-06-30]	DFND	0	820,425
Fiera Capital Corp	[2025-06-30]	OTR	523,414	790,810
Armistice Capital LLC	[2025-06-30]	SOLE	678,000	678,000
Logos Global Management LP	[2025-06-30]	SOLE	575,000	575,000
Two Sigma Advisers LP	[2025-06-30]	SOLE	492,129	512,430
Principal Financial Group Inc	[2025-06-30]	DFND	454,919	454,919
Massachusetts Financial Services Co /MA/	[2025-06-30]	SOLE	445,767	445,767
Two Sigma Investments LP	[2025-06-30]	SOLE	433,065	433,065
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	384,782	384,782
Susquehanna International Group LLP	[2025-06-30]	OTR	8,894	382,294
Hudson Bay Capital Management LP	[2025-06-30]	SOLE	345,952	345,952
Millennium Management LLC	[2025-06-30]	SOLE	276,502	291,502
TD Asset Management Inc	[2025-06-30]	SOLE	286,264	286,264
Woodline Partners LP	[2025-06-30]	SOLE	246,498	246,498
Jane Street Group LLC	[2025-06-30]	DFND	244,879	244,879
Morgan Stanley	[2025-06-30]	DFND	227,669	237,879
Citadel Advisors LLC	[2025-06-30]	DFND	237,717	237,717
Renaissance Technologies LLC	[2025-06-30]	SOLE	222,052	222,052
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