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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	18,589,387	18,599,195
Deep Track Capital LP	[2025-06-30]	SOLE	9,500,000	9,500,000
Vanguard Group Inc	[2025-06-30]	SOLE	0	6,863,353
BlackRock, Inc.	[2025-06-30]	SOLE	5,678,656	5,848,285
Baker Bros Advisors LP	[2025-06-30]	SOLE	5,457,881	5,457,881
Armistice Capital LLC	[2025-06-30]	SOLE	5,200,000	5,200,000
Point72 Asset Management LP	[2025-06-30]	DFND	0	3,336,250
State Street Corp	[2025-06-30]	DFND	2,649,591	2,830,074
Alpine Global Management, LLC	[2025-06-30]	SOLE	2,626,692	2,626,692
Morgan Stanley	[2025-06-30]	DFND	2,278,649	2,309,061
Two SEAS Capital LP	[2025-06-30]	SOLE	2,252,772	2,252,772
Perceptive Advisors LLC	[2025-06-30]	SOLE	2,137,890	2,137,890
Geode Capital Management LLC	[2025-06-30]	DFND	1,825,602	1,825,602
Woodline Partners LP	[2025-06-30]	SOLE	1,498,725	1,498,725
Stempoint Capital LP	[2025-06-30]	SOLE	1,244,352	1,400,860
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	1,067,666	1,188,578
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,138,951	1,162,091
Aberdeen Group plc	[2025-06-30]	DFND	844,705	844,705
UBS Group AG	[2025-06-30]	DFND	692,539	695,284
Norges Bank	[2025-06-30]	SOLE	687,662	687,662
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	661,126	661,146
Northern Trust Corp	[2025-06-30]	DFND	563,469	564,850
Adar1 Capital Management LLC	[2025-06-30]	SOLE	535,066	535,066
Citadel Advisors LLC	[2025-06-30]	DFND	485,592	485,592
ProSight Management LP	[2025-06-30]	SOLE	479,400	479,400
JPMorgan Chase & Co	[2025-06-30]	DFND	418,498	478,263
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	463,600	463,600
Connor Clark & Lunn Investment Management Ltd	[2025-06-30]	SOLE	448,515	448,515
Bank of America Corp /DE/	[2025-06-30]	DFND	13,134	421,726
Canada Pension Plan Investment Board	[2025-06-30]	SOLE	414,800	414,800
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