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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	12,981,962.0
BlackRock Inc.	[2023-03-31]	SOLE	9,896,916.0	10,087,420.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	1,822,165.0	9,749,543.0
T. Rowe Price Investment Management, Inc.	[2023-03-31]	SOLE	3,077,114.0	8,415,430.0
Deep Track Capital LP	[2023-03-31]	SOLE	6,500,000.0	6,500,000.0
State Street Corp	[2023-03-31]	DFND	5,992,566.0	6,325,205.0
Palo Alto Investors LP	[2023-03-31]	SOLE	5,889,491.0	5,889,491.0
Macquarie Group Ltd	[2023-03-31]	SOLE	4,009,387.0	4,052,364.0
Pictet Asset Management Sa	[2023-03-31]	DFND	1.0	3,930,763.0
William Blair Investment Management LLC	[2023-03-31]	SOLE	3,195,885.0	3,706,678.0
FMR LLC	[2023-03-31]	DFND	3,578,037.0	3,587,000.0
Franklin Resources Inc	[2023-03-31]	DFND	3,505,036.0	3,507,176.0
Bellevue Group AG	[2023-03-31]	DFND	3,293,102.0	3,293,102.0
Suvretta Capital Management LLC	[2023-03-31]	SOLE	2,932,138.0	2,932,138.0
Hudson Bay Capital Management LP	[2023-03-31]	SOLE	2,806,632.0	2,806,632.0
Geode Capital Management LLC	[2023-03-31]	DFND	2,625,675.0	2,625,675.0
Janus Henderson Group PLC	[2023-03-31]	DFND	0.0	2,561,169.0
AllianceBernstein LP	[2023-03-31]	DFND	2,229,036.0	2,474,388.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	2,162,951.0	2,372,577.0
Holocene Advisors LP	[2023-03-31]	SOLE	2,215,147.0	2,215,147.0
Ameriprise Financial Inc	[2023-03-31]	DFND	0.0	2,004,917.0
Samlyn Capital LLC	[2023-03-31]	DFND	1,977,556.0	1,977,556.0
Polar Capital Holdings Plc	[2023-03-31]	DFND	1,691,349.0	1,691,349.0
Loomis Sayles & Co L P	[2023-03-31]	DFND	1,604,410.0	1,628,518.0
Assenagon Asset Management S.A.	[2023-03-31]	SOLE	1,407,339.0	1,407,339.0
Novo Holdings A/S	[2023-03-31]	SOLE	1,339,304.0	1,339,304.0
Northern Trust Corp	[2023-03-31]	DFND	89,522.0	1,302,890.0
GW&K Investment Management LLC	[2023-03-31]	SOLE	1,262,808.0	1,262,808.0
Principal Financial Group Inc	[2023-03-31]	DFND	1,253,032.0	1,253,032.0
Citadel Advisors LLC	[2023-03-31]	DFND	1,081,802.0	1,081,802.0
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