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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Novo Holdings A/S	[2023-03-31]	SOLE	3,277,932.0	3,277,932.0
Vivo Capital LLC	[2023-03-31]	SOLE	3,015,545.0	3,015,545.0
Avoro Capital Advisors LLC	[2023-03-31]	SOLE	2,055,883.0	2,055,883.0
Bank of America Corp /DE/	[2023-03-31]	DFND	10,000.0	1,854,185.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	1,400,000.0
Samsara Biocapital LLC	[2023-03-31]	SOLE	1,008,437.0	1,008,437.0
PFM Health Sciences LP	[2023-03-31]	DFND	0.0	507,640.0
Capital World Investors	[2023-03-31]	DFND	418,499.0	418,499.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	132,200.0	132,200.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	17,818.0	61,700.0
Newtyn Management LLC	[2023-03-31]	SOLE	49,346.0	49,346.0
Citadel Advisors LLC	[2023-03-31]	DFND	46,842.0	46,842.0
Morgan Stanley	[2023-03-31]	DFND	0.0	43,195.0
Millennium Management LLC	[2023-03-31]	SOLE	19,917.0	19,917.0
Geode Capital Management LLC	[2023-03-31]	DFND	12,730.0	12,730.0
Cannell Capital LLC	[2023-03-31]	SOLE	12,594.0	12,594.0
Ancora Advisors LLC	[2023-03-31]	SOLE	908.0	908.0
Concourse Financial Group Securities Inc	[2023-03-31]	SOLE	0.0	0.0
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