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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Rubric Capital Management LP	[2025-06-30]	SOLE	3,909,806	3,909,806
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,100,506
Baker Bros Advisors LP	[2025-06-30]	SOLE	2,824,669	2,824,669
Tang Capital Management LLC	[2025-06-30]	OTR	0	2,328,609
Fairmount Funds Management LLC	[2025-06-30]	SOLE	1,772,839	1,772,839
Caption Management LLC	[2025-06-30]	SOLE	1,372,500	1,372,500
Braidwell LP	[2025-06-30]	SOLE	1,102,580	1,102,580
Morgan Stanley	[2025-06-30]	DFND	851,435	1,066,279
Millennium Management LLC	[2025-06-30]	SOLE	1,019,968	1,019,968
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	897,433	984,597
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	888,364	888,364
Point72 Asset Management LP	[2025-06-30]	DFND	0	848,549
FMR LLC	[2025-06-30]	DFND	804,715	806,898
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	787,605	791,305
Arrowstreet Capital Limited Partnership	[2025-06-30]	DFND	735,417	735,417
BlackRock, Inc.	[2025-06-30]	SOLE	634,848	700,637
Cubist Systematic Strategies, LLC	[2025-06-30]	DFND	0	657,475
Driehaus Capital Management LLC	[2025-06-30]	SOLE	500,740	647,980
Rice Hall James & Associates LLC	[2025-06-30]	SOLE	511,517	638,233
Connor Clark & Lunn Investment Management Ltd	[2025-06-30]	SOLE	623,689	623,689
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	560,481	598,059
Jane Street Group LLC	[2025-06-30]	DFND	586,392	597,692
Parkman Healthcare Partners LLC	[2025-06-30]	SOLE	488,796	488,796
ArrowMark Colorado Holdings LLC	[2025-06-30]	SOLE	465,899	465,899
Trexquant Investment LP	[2025-06-30]	SOLE	456,987	456,987
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	425,947
Squarepoint Ops LLC	[2025-06-30]	DFND	0	416,572
AQR Capital Management LLC	[2025-06-30]	DFND	372,593	389,106
Goldman Sachs Group Inc	[2025-06-30]	DFND	383,668	383,668
Deutsche Bank AG	[2025-06-30]	DFND	61,175	369,502
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