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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Vanguard Group Inc	[2025-06-30]	SOLE	0	515,278
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	421,322	421,322
Eversept Partners LP	[2025-06-30]	SOLE	257,154	257,154
JPMorgan Chase & Co	[2025-06-30]	DFND	256,443	256,443
BlackRock, Inc.	[2025-06-30]	SOLE	236,641	236,641
Citadel Advisors LLC	[2025-06-30]	DFND	223,005	223,005
Palo Alto Investors LP	[2025-06-30]	SOLE	187,911	187,911
Bank of America Corp /DE/	[2025-06-30]	DFND	0	168,534
UBS Group AG	[2025-06-30]	DFND	161,900	161,900
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	157,500	157,500
Catalio Capital Management LP	[2025-06-30]	SOLE	146,013	146,013
Avidity Partners Management LP	[2025-06-30]	SOLE	134,566	134,566
Marshall Wace LLP	[2025-06-30]	OTR	0	128,451
Goldman Sachs Group Inc	[2025-06-30]	DFND	109,404	109,404
C WorldWide Group Holding A/S	[2025-06-30]	DFND	100,000	100,000
Group One Trading LLC	[2025-06-30]	SOLE	97,900	97,900
Geode Capital Management LLC	[2025-06-30]	DFND	91,841	91,841
Silverback Asset Management LLC	[2025-06-30]	SOLE	70,000	70,000
Renaissance Technologies LLC	[2025-06-30]	SOLE	65,814	65,814
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	37,836	37,836
State Street Corp	[2025-06-30]	DFND	33,295	33,295
Millennium Management LLC	[2025-06-30]	SOLE	31,847	31,847
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	29,637
Birchview Capital LP	[2025-06-30]	SOLE	27,985	27,985
Ikarian Capital LLC	[2025-06-30]	SOLE	27,257	27,257
Morgan Stanley	[2025-06-30]	DFND	22,101	25,091
Northern Trust Corp	[2025-06-30]	DFND	18,889	18,910
Susquehanna International Group LLP	[2025-06-30]	OTR	0	16,600
GSA Capital Partners LLP	[2025-06-30]	SOLE	13,894	13,894
XTX Topco Ltd	[2025-06-30]	DFND	13,056	13,056
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