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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Baker Bros Advisors LP	[2025-06-30]	SOLE	6,651,429	6,651,429
Avoro Capital Advisors LLC	[2025-06-30]	SOLE	6,555,555	6,555,555
Vanguard Group Inc	[2025-06-30]	SOLE	0	5,510,211
BVF Inc/IL	[2025-06-30]	DFND	0	5,502,710
FMR LLC	[2025-06-30]	DFND	5,429,423	5,431,994
Wellington Management Group LLP	[2025-06-30]	DFND	0	5,372,061
Atlas Venture Life Science Advisors LLC	[2025-06-30]	SOLE	4,896,462	4,896,462
BlackRock, Inc.	[2025-06-30]	SOLE	4,048,527	4,148,260
Siren, L.L.C.	[2025-06-30]	DFND	3,428,150	3,428,150
State Street Corp	[2025-06-30]	DFND	1,436,817	1,554,431
Capital Research Global Investors	[2025-06-30]	DFND	1,262,182	1,262,182
Geode Capital Management LLC	[2025-06-30]	DFND	1,193,112	1,193,112
Driehaus Capital Management LLC	[2025-06-30]	SOLE	743,880	933,890
Jennison Associates LLC	[2025-06-30]	DFND	825,025	825,025
Redmile Group LLC	[2025-06-30]	SOLE	803,289	803,289
Merck & Co., Inc.	[2025-06-30]	DFND	0	772,165
Commodore Capital LP	[2025-06-30]	SOLE	750,000	750,000
Deerfield Management Company LP	[2025-06-30]	DFND	653,000	653,000
Eventide Asset Management LLC	[2025-06-30]	SOLE	562,990	562,990
UBS Group AG	[2025-06-30]	DFND	454,842	557,734
Citadel Advisors LLC	[2025-06-30]	DFND	552,387	552,387
Woodline Partners LP	[2025-06-30]	SOLE	498,111	498,111
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	454,761	496,450
Frontier Capital Management Co LLC	[2025-06-30]	SOLE	201,124	491,810
Massachusetts Financial Services Co /MA/	[2025-06-30]	SOLE	487,961	487,961
AJU IB Investment Co., Ltd.	[2025-06-30]	SOLE	457,059	457,059
Rock Springs Capital Management LP	[2025-06-30]	SOLE	450,374	450,374
Boxer Capital Management LLC	[2025-06-30]	SOLE	0	432,010
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	429,304	429,304
Northern Trust Corp	[2025-06-30]	DFND	401,309	401,699
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