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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Atlas Venture Life Science Advisors LLC	[2023-03-31]	SOLE	5,858,262.0	5,858,262.0
BVF Inc/IL	[2023-03-31]	DFND	0.0	4,739,004.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	826,824.0	4,611,560.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	4,291,018.0
Avoro Capital Advisors LLC	[2023-03-31]	SOLE	3,855,000.0	3,855,000.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	3,667,937.0
BlackRock Inc.	[2023-03-31]	SOLE	3,218,993.0	3,330,190.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	2,879,825.0	2,879,825.0
State Street Corp	[2023-03-31]	DFND	2,654,065.0	2,726,825.0
Redmile Group LLC	[2023-03-31]	SOLE	2,410,769.0	2,410,769.0
T. Rowe Price Investment Management, Inc.	[2023-03-31]	SOLE	705,359.0	1,968,175.0
Artal Group S.A.	[2023-03-31]	DFND	1,805,346.0	1,805,346.0
Rock Springs Capital Management LP	[2023-03-31]	SOLE	1,228,379.0	1,228,379.0
Wasatch Advisors LP	[2023-03-31]	SOLE	912,492.0	1,037,414.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	875,055.0	935,180.0
EcoR1 Capital LLC	[2023-03-31]	SOLE	796,093.0	796,093.0
Geode Capital Management LLC	[2023-03-31]	DFND	780,829.0	780,829.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	652,215.0	685,664.0
FMR LLC	[2023-03-31]	DFND	666,640.0	667,351.0
Deer Management Co LLC	[2023-03-31]	DFND	615,895.0	615,895.0
Aquilo Capital Management LLC	[2023-03-31]	SOLE	601,325.0	601,325.0
JPMorgan Chase & Co	[2023-03-31]	DFND	451,320.0	566,966.0
Candriam SCA	[2023-03-31]	SOLE	511,454.0	511,454.0
Barclays PLC	[2023-03-31]	SOLE	359,928.0	359,928.0
Massachusetts Financial Services Co /MA/	[2023-03-31]	SOLE	339,147.0	339,147.0
Northern Trust Corp	[2023-03-31]	DFND	17,262.0	336,673.0
Morgan Stanley	[2023-03-31]	DFND	306,559.0	326,322.0
Susquehanna International Group LLP	[2023-03-31]	DFND	72,677.0	311,177.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	298,497.0	298,497.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	296,796.0	296,843.0
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