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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Vida Ventures Advisors LLC	[2025-06-30]	SOLE	4,523,924	4,523,924
Gilead Sciences Inc	[2025-06-30]	SOLE	4,126,119	4,126,119
Bain Capital Life Sciences Investors, LLC	[2025-06-30]	SOLE	3,368,370	3,368,370
Price T Rowe Associates Inc /MD/	[2025-06-30]	SOLE	1,778,516	1,778,516
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,306,596
Insight Holdings Group, LLC	[2025-06-30]	DFND	0	989,054
Franklin Resources Inc	[2025-06-30]	DFND	695,027	695,027
MBB Public Markets I LLC	[2025-06-30]	SOLE	614,477	614,477
Catalio Capital Management LP	[2025-06-30]	SOLE	586,909	586,909
BlackRock, Inc.	[2025-06-30]	SOLE	531,460	533,467
Millennium Management LLC	[2025-06-30]	SOLE	452,560	452,560
KERA Capital Partners Inc	[2025-06-30]	SOLE	0	421,924
Peapod Lane Capital LLC	[2025-06-30]	SOLE	316,615	396,763
Citadel Advisors LLC	[2025-06-30]	DFND	364,689	364,689
Geode Capital Management LLC	[2025-06-30]	DFND	287,601	287,601
TD Asset Management Inc	[2025-06-30]	SOLE	252,196	252,196
Morgan Stanley	[2025-06-30]	DFND	149,008	202,038
Cubist Systematic Strategies, LLC	[2025-06-30]	DFND	0	144,623
Superstring Capital Management LP	[2025-06-30]	SOLE	142,542	142,542
Goldman Sachs Group Inc	[2025-06-30]	DFND	136,378	136,378
Renaissance Technologies LLC	[2025-06-30]	SOLE	122,417	122,417
Two Sigma Investments LP	[2025-06-30]	SOLE	120,584	120,584
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	118,606	118,606
Manufacturers Life Insurance Company the	[2025-06-30]	DFND	118,297	118,297
Susquehanna International Group LLP	[2025-06-30]	OTR	72,269	100,869
UBS Group AG	[2025-06-30]	DFND	97,562	98,158
AQR Capital Management LLC	[2025-06-30]	DFND	98,133	98,133
Two Sigma Advisers LP	[2025-06-30]	SOLE	90,200	94,300
State Street Corp	[2025-06-30]	DFND	91,300	91,300
Jane Street Group LLC	[2025-06-30]	DFND	87,769	87,769
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