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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Broadwood Capital Inc	[2025-06-30]	DFND	49,560,992	49,560,992
Vanguard Group Inc	[2025-06-30]	SOLE	0	8,397,078
Defender Capital LLC	[2025-06-30]	SOLE	0	6,785,177
Raffles Associates LP	[2025-06-30]	SOLE	5,392,088	5,392,088
Comerica Bank	[2025-06-30]	SOLE	4,600,000	4,600,000
Millennium Management LLC	[2025-06-30]	SOLE	2,600,577	2,600,577
Geode Capital Management LLC	[2025-06-30]	DFND	2,431,619	2,431,619
BlackRock, Inc.	[2025-06-30]	SOLE	2,260,748	2,260,748
Renaissance Technologies LLC	[2025-06-30]	SOLE	1,972,335	1,972,335
Jane Street Group LLC	[2025-06-30]	DFND	1,506,396	1,570,296
Dauntless Investment Group, LLC	[2025-06-30]	SOLE	0	1,205,930
GSA Capital Partners LLP	[2025-06-30]	SOLE	897,611	897,611
State Street Corp	[2025-06-30]	DFND	849,522	849,522
Morgan Stanley	[2025-06-30]	DFND	186,879	837,463
Susquehanna International Group LLP	[2025-06-30]	OTR	547,242	615,542
Squarepoint Ops LLC	[2025-06-30]	DFND	0	511,107
Northern Trust Corp	[2025-06-30]	DFND	510,462	510,462
Red Crane Wealth Management LLC	[2025-06-30]	SOLE	0	495,998
Cubist Systematic Strategies, LLC	[2025-06-30]	DFND	0	435,259
Citadel Advisors LLC	[2025-06-30]	DFND	420,881	420,881
Y-Intercept (Hong Kong) Ltd	[2025-06-30]	SOLE	405,043	405,043
Two Sigma Investments LP	[2025-06-30]	SOLE	317,977	317,977
Brevan Howard Capital Management LP	[2025-06-30]	DFND	308,877	308,877
Summittx Capital LP	[2025-06-30]	DFND	286,520	286,520
HRT Financial LP	[2025-06-30]	DFND	280,077	280,077
Royal Bank of Canada	[2025-06-30]	DFND	259,714	259,714
UBS Group AG	[2025-06-30]	DFND	226,045	227,600
Aster Capital Management (DIFC) Ltd	[2025-06-30]	SOLE	0	218,241
FMR LLC	[2025-06-30]	DFND	189,772	194,890
AQR Capital Management LLC	[2025-06-30]	DFND	190,555	190,555
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