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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2023-03-31]	DFND	16,368,970.0	16,394,677.0
HHLR Advisors Ltd	[2023-03-31]	OTR	0.0	5,130,367.0
BlackRock Inc.	[2023-03-31]	SOLE	3,861,173.0	4,127,953.0
RA Capital Management LP	[2023-03-31]	SOLE	0.0	2,436,223.0
Capital World Investors	[2023-03-31]	DFND	2,389,367.0	2,389,367.0
Federated Hermes Inc	[2023-03-31]	DFND	2,338,800.0	2,338,800.0
Polar Capital Holdings Plc	[2023-03-31]	DFND	1,975,631.0	1,975,631.0
Capital International Investors	[2023-03-31]	DFND	1,950,684.0	1,950,684.0
Janus Henderson Group PLC	[2023-03-31]	DFND	0.0	1,939,091.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	1,757,428.0
Johnson & Johnson	[2023-03-31]	DFND	0.0	1,629,173.0
AllianceBernstein LP	[2023-03-31]	DFND	1,281,613.0	1,577,947.0
Paradigm Biocapital Advisors LP	[2023-03-31]	SOLE	1,510,324.0	1,510,324.0
Massachusetts Financial Services Co /MA/	[2023-03-31]	SOLE	1,394,907.0	1,394,907.0
Matthews International Capital Management LLC	[2023-03-31]	SOLE	1,306,668.0	1,306,668.0
Avidity Partners Management LP	[2023-03-31]	SOLE	1,120,500.0	1,120,500.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	206,318.0	1,090,649.0
ArrowMark Colorado Holdings LLC	[2023-03-31]	SOLE	1,071,494.0	1,071,494.0
TimesSquare Capital Management LLC	[2023-03-31]	SOLE	820,770.0	1,063,610.0
Artisan Partners Limited Partnership	[2023-03-31]	SOLE	823,533.0	1,050,423.0
State Street Corp	[2023-03-31]	DFND	721,950.0	939,450.0
Nicholas Investment Partners LP	[2023-03-31]	SOLE	615,333.0	615,333.0
Braidwell LP	[2023-03-31]	SOLE	601,801.0	601,801.0
Samlyn Capital LLC	[2023-03-31]	DFND	598,428.0	598,428.0
Millennium Management LLC	[2023-03-31]	SOLE	542,002.0	578,202.0
JPMorgan Chase & Co	[2023-03-31]	DFND	475,870.0	555,586.0
Manufacturers Life Insurance Company the	[2023-03-31]	DFND	529,611.0	529,611.0
Bellevue Group AG	[2023-03-31]	DFND	507,254.0	507,254.0
Capital International, Inc./CA/	[2023-03-31]	DFND	504,520.0	504,520.0
Iron Triangle Partners LP	[2023-03-31]	SOLE	500,000.0	500,000.0
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