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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	25,604,078	25,670,311
Westfield Capital Management Co LP	[2025-06-30]	SOLE	4,518,717	6,472,547
HHLR Advisors Ltd	[2025-06-30]	OTR	0	5,984,550
BlackRock, Inc.	[2025-06-30]	SOLE	3,991,794	4,248,568
Suvretta Capital Management LLC	[2025-06-30]	SOLE	3,774,009	3,774,009
Deerfield Management Company LP	[2025-06-30]	DFND	2,962,338	2,962,338
Braidwell LP	[2025-06-30]	SOLE	2,542,104	2,542,104
Artisan Partners Limited Partnership	[2025-06-30]	SOLE	1,922,398	2,122,268
Janus Henderson Group PLC	[2025-06-30]	DFND	0	2,092,732
AllianceBernstein LP	[2025-06-30]	DFND	1,461,463	1,560,596
Balyasny Asset Management LP	[2025-06-30]	SOLE	1,322,633	1,322,633
Matthews International Capital Management LLC	[2025-06-30]	SOLE	1,293,052	1,293,052
State Street Corp	[2025-06-30]	DFND	804,739	1,119,691
Capital International Investors	[2025-06-30]	DFND	1,082,473	1,082,473
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,071,316	1,071,316
Federated Hermes Inc	[2025-06-30]	DFND	1,063,724	1,063,724
UBS Group AG	[2025-06-30]	DFND	1,009,456	1,021,556
ArrowMark Colorado Holdings LLC	[2025-06-30]	SOLE	983,510	983,510
IvyRock Asset Management (HK) Ltd	[2025-06-30]	SOLE	714,300	869,900
Tang Capital Management LLC	[2025-06-30]	OTR	0	830,000
Johnson & Johnson	[2025-06-30]	DFND	0	814,586
Millennium Management LLC	[2025-06-30]	SOLE	740,847	754,847
Two Sigma Advisers LP	[2025-06-30]	SOLE	689,100	716,100
Renaissance Technologies LLC	[2025-06-30]	SOLE	656,300	656,300
Ameriprise Financial Inc	[2025-06-30]	DFND	0	628,185
Morgan Stanley	[2025-06-30]	DFND	455,011	518,289
HSBC Holdings PLC	[2025-06-30]	SOLE	375,718	476,247
Geode Capital Management LLC	[2025-06-30]	DFND	473,742	473,742
Massachusetts Financial Services Co /MA/	[2025-06-30]	SOLE	445,529	445,529
Canada Pension Plan Investment Board	[2025-06-30]	SOLE	444,900	444,900
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