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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Novo Holdings A/S	[2025-06-30]	SOLE	15,814,845	15,814,845
Vanguard Group Inc	[2025-06-30]	SOLE	0	5,715,382
Millennium Management LLC	[2025-06-30]	SOLE	2,360,881	2,360,881
BlackRock, Inc.	[2025-06-30]	SOLE	2,268,781	2,292,909
UBS Group AG	[2025-06-30]	DFND	1,689,368	1,689,368
Susquehanna International Group LLP	[2025-06-30]	OTR	981,341	1,089,441
Geode Capital Management LLC	[2025-06-30]	DFND	1,088,384	1,088,384
Goldman Sachs Group Inc	[2025-06-30]	DFND	951,172	951,172
Jane Street Group LLC	[2025-06-30]	DFND	847,159	847,159
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	391,109	391,109
State Street Corp	[2025-06-30]	DFND	351,164	351,164
AQR Capital Management LLC	[2025-06-30]	DFND	329,348	329,348
Marshall Wace LLP	[2025-06-30]	OTR	0	304,482
SBI Securities Co., Ltd.	[2025-06-30]	DFND	303,186	303,186
XTX Topco Ltd	[2025-06-30]	DFND	188,891	188,891
Northern Trust Corp	[2025-06-30]	DFND	157,929	157,929
DnB Asset Management AS	[2025-06-30]	OTR	0	148,656
Morgan Stanley	[2025-06-30]	DFND	146,980	147,404
Virtu Financial LLC	[2025-06-30]	DFND	122,409	122,409
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	99,501	99,501
Jain Global LLC	[2025-06-30]	SOLE	98,741	98,741
Point72 Asia (Singapore) Pte. Ltd.	[2025-06-30]	DFND	0	73,396
HRT Financial LP	[2025-06-30]	DFND	65,175	65,175
Balyasny Asset Management LP	[2025-06-30]	SOLE	57,070	57,070
IEQ Capital LLC	[2025-06-30]	OTR	0	53,554
Tower Research Capital LLC (TRC)	[2025-06-30]	DFND	52,348	52,348
Banco Santander, S.A.	[2025-06-30]	SOLE	0	49,534
Belvedere Trading LLC	[2025-06-30]	SOLE	49,005	49,005
Citigroup Inc	[2025-06-30]	DFND	45,133	45,133
Cerity Partners LLC	[2025-06-30]	DFND	0	42,512
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