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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
PRIMECAP Management Co/CA/	[2025-06-30]	SOLE	4,759,481	5,164,681
FMR LLC	[2025-06-30]	DFND	4,259,643	4,261,368
Morgan Stanley	[2025-06-30]	DFND	3,523,242	3,557,048
BlackRock, Inc.	[2025-06-30]	SOLE	2,651,334	2,690,798
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,243,091
Deerfield Management Company LP	[2025-06-30]	DFND	1,890,000	1,890,000
BNP Paribas Asset Management Holding S.A.	[2025-06-30]	DFND	0	1,168,513
Millennium Management LLC	[2025-06-30]	SOLE	1,166,527	1,166,527
Deutsche Bank AG	[2025-06-30]	DFND	759	1,125,861
Silvercrest Asset Management Group LLC	[2025-06-30]	SOLE	526,726	930,557
Geode Capital Management LLC	[2025-06-30]	DFND	929,397	929,397
State Street Corp	[2025-06-30]	DFND	752,782	794,185
Braidwell LP	[2025-06-30]	SOLE	752,541	752,541
Rock Springs Capital Management LP	[2025-06-30]	SOLE	651,100	651,100
Parkman Healthcare Partners LLC	[2025-06-30]	SOLE	605,029	605,029
JPMorgan Chase & Co	[2025-06-30]	DFND	530,370	591,684
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	484,578	489,880
Bank of America Corp /DE/	[2025-06-30]	DFND	6,389	481,268
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	385,939	426,109
GSA Capital Partners LLP	[2025-06-30]	SOLE	423,725	423,725
Northern Trust Corp	[2025-06-30]	DFND	349,715	349,715
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	313,738	313,738
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	309,651	309,651
Jefferies Financial Group Inc.	[2025-06-30]	DFND	285,110	285,110
UBS Group AG	[2025-06-30]	DFND	275,795	275,895
Barclays PLC	[2025-06-30]	SOLE	272,646	272,646
CFM Wealth Partners LLC	[2025-06-30]	SOLE	0	264,039
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	260,418	260,418
Renaissance Technologies LLC	[2025-06-30]	SOLE	251,310	251,310
Tudor Investment Corp ET AL	[2025-06-30]	DFND	241,051	241,051
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